Circle Cardiovascular Imaging vs Eyenuk
A retinal camera and a CT scanner feed different software, and the two vendors sell to different clinics.
Eyenuk describes EyeArt as autonomous grading of diabetic retinopathy with no physician overread, for adults with diabetes not previously diagnosed with it. The vendor says it is cleared with the Canon CR-2 AF, Canon CR-2 Plus AF and Topcon NW400 cameras and integrates with Epic. openFDA lists EyeArt as K200667 (August 2020) and version 2.2.0 as K223357 (June 2023). The homepage states 96% sensitivity and 88% specificity for more than mild DR, while a 2023 release citing trial NCT04984200 gives 94.4% and 91.1%. The billing code cited is CPT 92229, and HIPAA, SOC 2 Type 2 and ISO 13485:2016 are vendor statements. A primary care clinic or screening program with a fundus camera is the EyeArt buyer.
StrokeSENS is Circle's acute stroke CT software, with ASPECTS cleared in July 2025 (K250221) and LVO triage in October 2021 (K212261), next to the cardiac MR and CT platform. A stroke center reading acute CT is the Circle buyer.
Radiology · Reviewed November 2, 2026
Circle Cardiovascular Imaging
by Circle Cardiovascular Imaging Inc. · founded 2007
cvi42 cardiac MR and CT software with FDA-cleared AI coronary plaque analysis and StrokeSENS acute stroke tools.
Eyenuk
by Eyenuk, Inc.
EyeArt is FDA-cleared autonomous AI that grades diabetic retinopathy from retinal photos, with no physician overread needed.
When to pick each one
Circle Cardiovascular Imaging
- StrokeSENS ASPECTS cleared July 2025
- Cardiac MR and CT in one platform
- StrokeSENS LVO triage cleared October 2021
Eyenuk
- Diabetic retinopathy grading from retinal photos
- Vendor says cleared with Canon and Topcon cameras
- Vendor says it integrates with Epic
Score
Each row shows points earned of points available under the published rubric.
Circle Cardiovascular Imaging
42of 100
Eyenuk
71of 100
| Dimension | Circle Cardiovascular Imaging | Eyenuk | Difference |
|---|---|---|---|
| FDA clearance | 18 / 18 | 18 / 18 | 0 |
| HIPAA / SOC2 / BAA | 0 / 10 | 10 / 10 | -10 |
| EHR integrations (count) | 0 / 4.2 | 0 / 4.2 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 2.4 | 0 / 2.4 | 0 |
| Peer-reviewed papers | 0 / 18.2 | 18.2 / 18.2 | -18.2 |
| RCT / meta-analysis / systematic review | 0 / 7.8 | 7.8 / 7.8 | -7.8 |
| Funding & adoption signal | 8.4 / 12 | 3 / 12 | +5.4 |
| Pricing transparency | 2.5 / 5 | 2.5 / 5 | 0 |
| Years in market | 6 / 6 | 0 / 6 | +6 |
Scroll horizontally to see every column.
Pricing
Circle Cardiovascular Imaging
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Eyenuk
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Evidence
Circle Cardiovascular Imaging
FDA decisions
K251027 (opens in new tab)510(k)2025-10-27
cvi42 Coronary Plaque Software Application
K250221 (opens in new tab)510(k)2025-07-01
StrokeSENS ASPECTS Software Application
K242781 (opens in new tab)510(k)2024-10-15
cvi42 Software Application
K241038 (opens in new tab)510(k)2024-06-07
Cardiac CT Function Software Application
K232661 (opens in new tab)510(k)2023-12-07
Myocardial Strain Software Application
Show 7 more
K222593 (opens in new tab)510(k)2023-01-18
TruPlan Computed Tomography Imaging Software
K213998 (opens in new tab)510(k)2022-07-28
cvi42 Auto Imaging Software Application
K212261 (opens in new tab)510(k)2021-10-14
StrokeSENS LVO
K202212 (opens in new tab)510(k)2021-02-19
TruPlan
K141480 (opens in new tab)510(k)2014-08-22
CVI42
K111373 (opens in new tab)510(k)2011-08-23
CT42 Cardiac CT Software
K082628 (opens in new tab)510(k)2008-11-20
CMR42 Cardiac MRI Imaging System
Eyenuk
FDA decisions
K223357 (opens in new tab)510(k)2023-06-16
EyeArt v2.2.0
K200667 (opens in new tab)510(k)2020-08-03
EyeArt
Peer-reviewed
5 PubMed records name Eyenuk.
- Diagnostic Accuracy of the EyeArt Artificial Intelligence System for Diabetic Retinopathy: A Systematic Review and Meta-Analysis. (opens in new tab)
- A pilot cost-analysis study comparing AI-based EyeArt® and ophthalmologist assessment of diabetic retinopathy in minority women in Oslo, Norway. (opens in new tab)
- [Use of Artificial Intelligence in Diabetic Retinopathy Screening: Experience in a Health Service in Santiago, Chile]. (opens in new tab)
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Circle Cardiovascular Imaging | Eyenuk |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | 2007 | n/a |
| HQ | CA | US |
Scroll horizontally to see both columns.
Common questions
Open the full radiology comparison
Acute-care triage, mammography screening, CCTA plaque analysis, mobile MRI. 30+ FDA-cleared platforms across stroke, oncology, cardiac. Enterprise sales only — we compared what's deployed where.