Circle Cardiovascular Imaging vs HeartFlow
HeartFlow's 10-K puts 2025 revenue at $176.0M, 98% of it from FFRct, and describes substantially all revenue as pay-per-click. The company trades on Nasdaq as HTFL. FFRct Analysis turns a coronary CT angiogram into CT-derived fractional flow reserve processed in the vendor's cloud, and its first clearance was a 2014 De Novo, DEN130045. Plaque Analysis was at 489 US accounts on December 31, 2025.
Circle Cardiovascular Imaging sells cvi42 across cardiac MR, cardiac CT, vascular CT and interventional planning. Its coronary plaque software was cleared as K251027 in October 2025. No public price is listed.
For a cardiology service that wants CT-derived fractional flow reserve before revascularization, Circle loses: its homepage module list has plaque analysis and no FFR module. A cardiac imaging lab that reads MR as well as CT buys Circle.
Radiology · Reviewed November 2, 2026
Circle Cardiovascular Imaging
by Circle Cardiovascular Imaging Inc. · founded 2007
cvi42 cardiac MR and CT software with FDA-cleared AI coronary plaque analysis and StrokeSENS acute stroke tools.
HeartFlow
by HeartFlow · founded 2007
Coronary CT angiogram analysis: CT-derived fractional flow reserve (FFRct), plaque analysis and a CCTA reading aid.
When to pick each one
Circle Cardiovascular Imaging
- Reads cardiac MR as well as cardiac CT
- Coronary plaque software cleared October 2025
- Interventional planning module
HeartFlow
- CT-derived fractional flow reserve in the cloud
- Nasdaq-listed, 2025 revenue $176.0M
- Pay-per-use revenue model per its 10-K
Score
Each row shows points earned of points available under the published rubric.
Circle Cardiovascular Imaging
42of 100
HeartFlow
66of 100
| Dimension | Circle Cardiovascular Imaging | HeartFlow | Difference |
|---|---|---|---|
| FDA clearance | 18 / 18 | 18 / 18 | 0 |
| HIPAA / SOC2 / BAA | 0 / 10 | 0 / 10 | 0 |
| EHR integrations (count) | 0 / 4.2 | 0 / 4.2 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 2.4 | 0 / 2.4 | 0 |
| Peer-reviewed papers | 0 / 18.2 | 12.7 / 18.2 | -12.7 |
| RCT / meta-analysis / systematic review | 0 / 7.8 | 7.8 / 7.8 | -7.8 |
| Funding & adoption signal | 8.4 / 12 | 8.4 / 12 | 0 |
| Pricing transparency | 2.5 / 5 | 2.5 / 5 | 0 |
| Years in market | 6 / 6 | 6 / 6 | 0 |
Scroll horizontally to see every column.
Pricing
Circle Cardiovascular Imaging
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
HeartFlow
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Per study | n/a | n/a | No public list price. The 10-K describes revenue as pay-per-use. |
Evidence
Circle Cardiovascular Imaging
FDA decisions
K251027 (opens in new tab)510(k)2025-10-27
cvi42 Coronary Plaque Software Application
K250221 (opens in new tab)510(k)2025-07-01
StrokeSENS ASPECTS Software Application
K242781 (opens in new tab)510(k)2024-10-15
cvi42 Software Application
K241038 (opens in new tab)510(k)2024-06-07
Cardiac CT Function Software Application
K232661 (opens in new tab)510(k)2023-12-07
Myocardial Strain Software Application
Show 7 more
K222593 (opens in new tab)510(k)2023-01-18
TruPlan Computed Tomography Imaging Software
K213998 (opens in new tab)510(k)2022-07-28
cvi42 Auto Imaging Software Application
K212261 (opens in new tab)510(k)2021-10-14
StrokeSENS LVO
K202212 (opens in new tab)510(k)2021-02-19
TruPlan
K141480 (opens in new tab)510(k)2014-08-22
CVI42
K111373 (opens in new tab)510(k)2011-08-23
CT42 Cardiac CT Software
K082628 (opens in new tab)510(k)2008-11-20
CMR42 Cardiac MRI Imaging System
HeartFlow
FDA decisions
K250902 (opens in new tab)510(k)2025-07-18
HeartFlow Analysis
K213857 (opens in new tab)510(k)2022-10-14
HeartFlow Analysis
K203329 (opens in new tab)510(k)2021-01-08
HeartFlow Analysis
K190925 (opens in new tab)510(k)2019-08-15
K182035 (opens in new tab)510(k)2018-12-06
Show 3 more
K161772 (opens in new tab)510(k)2016-08-24
K152733 (opens in new tab)510(k)2016-01-13
DEN130045 (opens in new tab)De Novo2014-11-26
FFRct
Peer-reviewed
2 PubMed records name HeartFlow.
- Prognostic value of CT-derived fractional flow reserve for major adverse cardiovascular events in patients with suspected or known coronary artery disease: a systematic review and meta-analysis. (opens in new tab)
- Diagnostic Performance of AI-enabled Plaque Quantification from Coronary CT Angiography Compared with Intravascular Ultrasound. (opens in new tab)
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Circle Cardiovascular Imaging | HeartFlow |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | 2007 | 2007 |
| HQ | CA | US |
Scroll horizontally to see both columns.
Common questions
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Acute-care triage, mammography screening, CCTA plaque analysis, mobile MRI. 30+ FDA-cleared platforms across stroke, oncology, cardiac. Enterprise sales only — we compared what's deployed where.