MedAI Verdict
All comparisons

Freenome vs Vesta

Valar's Vesta suits a urologist whose non-muscle-invasive bladder cancer patient is weighing BCG. The vendor says its CLIA-certified lab runs the AI on the routine H&E slide and reports about three days after receipt. Risk Stratify adds recurrence and progression scores, and the vendor says a high recurrence score means 2x the risk of high-grade recurrence over up to 24 months. Valar raised a $22 million Series A on May 22, 2024. The testimonials on the product page are vendor-selected and undated.

Freenome's SimpleScreen CRC is a qualitative cell-free DNA blood test for colorectal cancer screening, approved as PMA P250029. Vesta applies to patients already diagnosed with bladder cancer, while Freenome's indication is screening of average-risk adults 45 and older, with colonoscopy after a positive result. A general practitioner screening those adults would order the Freenome test.

Pathology · Reviewed November 2, 2026

Freenome logo

Freenome

by Freenome · founded 2014

FDA-approved SimpleScreen CRC blood test for colorectal cancer screening in adults 45 and older at average risk.

Vesta logo

Vesta

by Valar Labs

Lab test run in a CLIA lab: AI on routine bladder cancer slides predicts BCG response, ordered by urologists.

When to pick each one

Freenome

  • Qualitative blood test, colonoscopy after a positive
  • PMA-approved, P250029
Read the full Freenome review

Vesta

  • AI test on routine bladder H&E slides
  • Recurrence and progression scores from Risk Stratify
  • Vendor says report arrives about 3 days after receipt
Read the full Vesta review

Score

Each row shows points earned of points available under the published rubric.

Freenome

40of 100

Competitive

Vesta

16of 100

Tracked
Score by dimension for Freenome and Vesta
DimensionFreenomeVestaDifference
FDA clearance18 / 180 / 18+18
HIPAA / SOC2 / BAA0 / 100 / 100
EHR integrations (count)0 / 4.20 / 4.20
Top-3 EHR coverage (Epic / Oracle / Athena)0 / 2.40 / 2.40
Peer-reviewed papers0 / 218.4 / 21-8.4
RCT / meta-analysis / systematic review0 / 7.80 / 7.80
Funding & adoption signal8.4 / 123 / 12+5.4
Pricing transparency2.5 / 52.5 / 50
Years in market6 / 60 / 6+6

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How scores are computed

Pricing

Freenome

TierMonthlyAnnualNotes
Enterprisen/an/aNo public price.

Vesta

TierMonthlyAnnualNotes
Enterprisen/an/aNo public price.

Evidence

Freenome

FDA decisions

Vesta

FDA decisions

No FDA decision cited in our research as of November 2, 2026.

Peer-reviewed

1 PubMed record names Vesta.

Compliance and integrations

Documented from each vendor’s own pages.

SpecFreenomeVesta
Free tierNo / unverifiedNo / unverified
HIPAANo / unverifiedNo / unverified
SOC 2 Type IINo / unverifiedNo / unverified
EHR integrationsNot specifiedNot specified
Founded2014n/a
HQUSn/a

Scroll horizontally to see both columns.

Common questions

Open the full pathology comparison

Digital pathology workflows with FDA-cleared cancer detection (prostate, breast, colon), IHC scoring (HER2, Ki67), and AI-powered image management. Tempus, PathAI, Proscia dominate.