GRAIL vs Vesta

Both are lab-run tests, and neither is software a clinic installs. Vesta is performed in Valar Labs' CLIA-certified laboratory, and a urologist orders it. Galleri is processed in GRAIL's own CLIA lab, where a machine-learning classifier reads cell-free DNA methylation to detect a cancer signal and predict its tissue of origin.

GRAIL's site says Galleri has not been cleared or approved, and openFDA shows no 510(k) under Valar Labs. openFDA shows no 510(k) under Valar Labs, and GRAIL's site says Galleri has not been cleared or approved. PubMed lists J Urol and Eur Urol Oncol papers on Vesta's biomarker under a Valar Labs affiliation.

BCGPredict is built for a urologist weighing BCG in a patient with non-muscle-invasive bladder cancer. GRAIL describes Galleri as screening for cancers before they become symptomatic, for an adult 50 or older. The two serve different patients and are ordered by different clinicians.