UpToDate Lexidrug

What is Lexidrug and who sells it?

Wolters Kluwer describes it as "the resource you need to stay current and make informed medication and therapeutic decisions," made up of "continuously updated drug databases and interactive tools" (Wolters Kluwer product page, October 2026). The product was Lexicomp until it was renamed Lexidrug under the UpToDate brand.

Wolters Kluwer N.V. is a listed company headquartered in Alphen aan den Rijn, the Netherlands, and UpToDate is its clinical decision support brand.

What does Lexidrug do well?

The product page lists interactive tools for drug interaction analysis, drug identification, medical calculations and drug comparisons, and Trissel's IV compatibility tool for compatibility, preparation, administration and stability. Two features matter most to a buyer. The IV compatibility tool is useful for nursing and pharmacy workflows, and the dosing guidance covers renal and hepatic impairment, obesity, pediatric, neonatal, geriatric and pregnancy considerations. The page also lists off-label uses, toxicology, infectious disease, allergy and pharmacogenomic content, patient education materials, a mobile app with offline download and, as a premium add-on, Facts and Comparisons eAnswers.

The independent evidence tested Lexicomp, the product's former name. A comparison of five common drug-drug interaction software programs (PubMed 27843962) ranked Lexicomp and Micromedex at the top for accuracy and completeness. In a Janusmed comparison published in Basic and Clinical Pharmacology and Toxicology in 2023, of 109 alerts rated C or D, 82% received an alert of similar significance in Lexicomp against 69% in Micromedex. Yale New Haven replaced Micromedex with Lexicomp in September 2022, according to the Yale library.

Where does Lexidrug fall short?

Alert volume is the concern in the literature. A secondary summary of a renal transplant study reports that 4.2% of Lexicomp-flagged interactions were judged clinically relevant against 8.2% for Micromedex. A low relevant share is the profile of an alert-fatigue problem.

Agreement across interaction checkers is low. A 2025 analysis of SSRI interactions found 16% to 24% agreement across tools (secondary source), so a clinician who relies on one checker should expect another to stay silent on some interactions.

The product pages describe no AI features and do not state HIPAA, SOC 2 or HITRUST. FDA status is not stated, and a reference database is not a cleared device.

How much does Lexidrug cost?

Enterprise pricing is not public and runs through a contact form. A personal subscription exists. App-store listings show $29.99 a month, with a 14-day free trial of the Hospital Pharmacist package on Google Play (October 2026), and Wolters Kluwer sells and renews personal subscriptions online at store.uptodate.com.

What does the evidence say?

No peer-reviewed study of Lexidrug as a product exists in the sources. The interaction-checker comparisons above include Lexicomp. They measure how many interactions a tool detects and how severe it rates them, and they do not show that using one tool over another changes patient outcomes.

How does it compare with Micromedex, Epocrates and Drugs.com?

The usual set is Micromedex, Clinical Pharmacology, Facts and Comparisons, Epocrates, the Medscape Drug Interaction Checker, Drugs.com and Skyscape. Micromedex is the closest rival in the published comparisons, and the two tied at the top on accuracy in the five-program study. Because agreement between checkers is low, a hospital choosing between them should run its most common queries through both.

Who is Lexidrug for?

• A hospital pharmacy that verifies orders against a reference database and wants IV compatibility next to dosing.
• A nurse practitioner or physician at a hospital whose informatics team has licensed the enterprise product.
• A pharmacy student or hospital pharmacist who will use the mobile app offline, on the personal subscription.
• Not for a clinician who wants an AI summary of the literature.

The verdict

A hospital pharmacy that already runs on Micromedex has little reason to switch for accuracy alone, since the comparisons place the two together. A pharmacy without a reference database, or one that wants Trissel's IV compatibility in the same product, should buy Lexidrug. An individual clinician who wants a lookup tool for $29.99 a month gets one, and anyone who wants AI summaries or a free tool does not.