Adonis vs Waystar
Adonis agents research denials and prepare appeals, per the vendor, and Waystar lists denial recovery inside a wider platform that also covers eligibility, estimates, authorizations, remittance and patient payments. For a specialty group on athenahealth, ModMed or NextGen with a denials backlog, Adonis names those EHRs on its partner list while Waystar's homepage names none, which makes Waystar the weaker fit. Adonis customers named by MedCity include Mount Sinai, Baptist Health South Florida, AdventHealth and ApolloMD. The vendor reports a 67% denial reduction at ApolloMD, with no baseline or period. Waystar suits a health system billing office that wants front-end clearance and patient payments on the same platform as its denial recovery. It has traded on Nasdaq (WAY) since June 2024 and says it covers 1M+ providers. Adonis, with $40M raised in a March 2026 Series C, is the vendor to weigh when the problem is claims already stalled with a payer.
Billing & coding · Reviewed November 2, 2026
When to pick each one
Adonis
- Epic, athenahealth, ModMed and NextGen on partner list
- AI agents for denials and appeals, vendor-stated
- MedCity names Mount Sinai and AdventHealth as customers
Waystar
- Nasdaq-listed since June 2024
- Eligibility through patient payments on one platform
- Vendor says it reaches 1M+ providers
Score
Each row shows points earned of points available under the published rubric.
Adonis
53of 100
Waystar
33of 100
| Dimension | Adonis | Waystar | Difference |
|---|---|---|---|
| HIPAA / SOC2 / BAA | 10 / 10 | 10 / 10 | 0 |
| EHR integrations (count) | 9.1 / 18.2 | 0 / 18.2 | +9.1 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 5.6 / 8 | 0 / 8 | +5.6 |
| Bidirectional write-back | 0 / 5.2 | 0 / 5.2 | 0 |
| Peer-reviewed papers | 0 / 7 | 0 / 7 | 0 |
| RCT / meta-analysis / systematic review | 0 / 3 | 0 / 3 | 0 |
| Funding & adoption signal | 8.4 / 12 | 12 / 12 | -3.6 |
| Pricing transparency | 3.3 / 6.5 | 3.3 / 6.5 | 0 |
| Years in market | 4.2 / 6 | 0 / 6 | +4.2 |
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Pricing
Adonis
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Waystar
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. Enterprise contracts. |
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Adonis | Waystar |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Epic, athenahealth, AdvancedMD, ModMed, NextGen Healthcare, Canvas | Not specified |
| Founded | 2022 | n/a |
| HQ | US | US |
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Common questions
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Autonomous coding (CodaMetrix #1 KLAS 2026), denial prevention, prior-auth automation. The single fastest path to ROI in healthcare AI is RCM — these tools deliver it.


