Amperos vs Waystar
Waystar is Nasdaq-listed (WAY, IPO June 2024, per its 10-K) and, per Fierce Healthcare, closed its acquisition of Iodine Software around October 1, 2025. A hospital patient financial services team wanting financial clearance, claims, denial recovery and patient payments under one contract would buy it. The vendor says it reaches 60% of the U.S. patient population and 1M+ providers. Its homepage shows HITRUST, SOC 2, PCI and HIPAA badges with no scope given.
Amperos has a narrower job. An orthopedic group like Precision Orthopedics and Sports Medicine, a named customer, hands it denied claims, and the vendor's press release cites over 3,000 clinical locations. Its Series A was announced April 22, 2026, led by Bessemer Venture Partners. The site shows a HIPAA badge and an AICPA SOC badge, with SOC 2 not written out.
For a health system RCM director who wants one contract from clearance through patient payments, Waystar is the buy and Amperos is the add-on for denied claims, since Waystar's homepage lists eligibility, estimates, authorizations, remittance and patient payments.
Billing & coding · Reviewed November 2, 2026
When to pick each one
Amperos
- Denial management run by agents plus RCM specialists
- Series A announced April 22, 2026, Bessemer lead
- Names Precision Orthopedics and Sports Medicine as a customer
Waystar
- Public company, Nasdaq WAY since June 2024
- Eligibility through patient payments on one platform
- Vendor says it reaches 1M+ providers
Score
Each row shows points earned of points available under the published rubric.
Amperos
41of 100
Waystar
33of 100
| Dimension | Amperos | Waystar | Difference |
|---|---|---|---|
| HIPAA / SOC2 / BAA | 10 / 10 | 10 / 10 | 0 |
| EHR integrations (count) | 9.1 / 18.2 | 0 / 18.2 | +9.1 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 5.6 / 8 | 0 / 8 | +5.6 |
| Bidirectional write-back | 0 / 5.2 | 0 / 5.2 | 0 |
| Peer-reviewed papers | 0 / 7 | 0 / 7 | 0 |
| RCT / meta-analysis / systematic review | 0 / 3 | 0 / 3 | 0 |
| Funding & adoption signal | 3 / 12 | 12 / 12 | -9 |
| Pricing transparency | 3.3 / 6.5 | 3.3 / 6.5 | 0 |
| Years in market | 0 / 6 | 0 / 6 | 0 |
Scroll horizontally to see every column.
Pricing
Amperos
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Waystar
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. Enterprise contracts. |
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Amperos | Waystar |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | eClinicalWorks, athenahealth, NextGen, Epic, ModMed, Dentrix | Not specified |
| Founded | n/a | n/a |
| HQ | US | US |
Scroll horizontally to see both columns.
Common questions
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Autonomous coding (CodaMetrix #1 KLAS 2026), denial prevention, prior-auth automation. The single fastest path to ROI in healthcare AI is RCM — these tools deliver it.

