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Amperos vs Waystar

Waystar is Nasdaq-listed (WAY, IPO June 2024, per its 10-K) and, per Fierce Healthcare, closed its acquisition of Iodine Software around October 1, 2025. A hospital patient financial services team wanting financial clearance, claims, denial recovery and patient payments under one contract would buy it. The vendor says it reaches 60% of the U.S. patient population and 1M+ providers. Its homepage shows HITRUST, SOC 2, PCI and HIPAA badges with no scope given.

Amperos has a narrower job. An orthopedic group like Precision Orthopedics and Sports Medicine, a named customer, hands it denied claims, and the vendor's press release cites over 3,000 clinical locations. Its Series A was announced April 22, 2026, led by Bessemer Venture Partners. The site shows a HIPAA badge and an AICPA SOC badge, with SOC 2 not written out.

For a health system RCM director who wants one contract from clearance through patient payments, Waystar is the buy and Amperos is the add-on for denied claims, since Waystar's homepage lists eligibility, estimates, authorizations, remittance and patient payments.

Billing & coding · Reviewed November 2, 2026

AM

Amperos

by Amperos Health

Agentic AI that works denied insurance claims through payer portals and recovers provider revenue.

Waystar logo

Waystar

by Waystar

AI-powered healthcare payments platform for revenue cycle: eligibility, authorizations, claims, denials and patient payments (AltitudeAI).

When to pick each one

Amperos

  • Denial management run by agents plus RCM specialists
  • Series A announced April 22, 2026, Bessemer lead
  • Names Precision Orthopedics and Sports Medicine as a customer
Read the full Amperos review

Waystar

  • Public company, Nasdaq WAY since June 2024
  • Eligibility through patient payments on one platform
  • Vendor says it reaches 1M+ providers
Read the full Waystar review

Score

Each row shows points earned of points available under the published rubric.

Amperos

41of 100

Competitive

Waystar

33of 100

Competitive
Score by dimension for Amperos and Waystar
DimensionAmperosWaystarDifference
HIPAA / SOC2 / BAA10 / 1010 / 100
EHR integrations (count)9.1 / 18.20 / 18.2+9.1
Top-3 EHR coverage (Epic / Oracle / Athena)5.6 / 80 / 8+5.6
Bidirectional write-back0 / 5.20 / 5.20
Peer-reviewed papers0 / 70 / 70
RCT / meta-analysis / systematic review0 / 30 / 30
Funding & adoption signal3 / 1212 / 12-9
Pricing transparency3.3 / 6.53.3 / 6.50
Years in market0 / 60 / 60

Scroll horizontally to see every column.

How scores are computed

Pricing

Amperos

TierMonthlyAnnualNotes
Enterprisen/an/aNo public price.

Waystar

TierMonthlyAnnualNotes
Enterprisen/an/aNo public price. Enterprise contracts.

Compliance and integrations

Documented from each vendor’s own pages.

SpecAmperosWaystar
Free tierNo / unverifiedNo / unverified
HIPAAYesYes
SOC 2 Type IIYesYes
EHR integrationseClinicalWorks, athenahealth, NextGen, Epic, ModMed, DentrixNot specified
Foundedn/an/a
HQUSUS

Scroll horizontally to see both columns.

Common questions

Open the full billing & coding comparison

Autonomous coding (CodaMetrix #1 KLAS 2026), denial prevention, prior-auth automation. The single fastest path to ROI in healthcare AI is RCM — these tools deliver it.