Harrison.ai vs Pearl
Harrison.ai, the company behind Annalise, sells chest X-ray, head CT and chest CT reading to hospitals, emergency departments and teleradiology services. NHS Grampian figures in a Scottish Health Technologies Group summary give sensitivity of 78%, specificity of 91%, positive predictive value of 3% and negative predictive value of 99.99%. A Radiology study of 5,235 patients found Annalise Enterprise CXR v3.8 and six other devices all produced more false positives than radiologist reports. Annalise shows nine openFDA decisions, from CXR Triage Pneumothorax in February 2022 to Annalise Enterprise in March 2026 (applicant Harrison-AI Medical Pty, Ltd.), while press coverage says twelve.
Pearl reads dental radiographs, and a hospital radiology department and a dental practice do not buy the same product. Second Opinion has eight openFDA decisions, from March 2022 to November 2025, and marks up to 18 findings per image on bitewing, periapical and panoramic films. Pearl is for a dental support organization standardizing reads across offices. Annalise is for an emergency department with chest films and head CTs.
Radiology · Reviewed November 2, 2026

Harrison.ai
by Harrison.ai
Imaging AI for chest X-ray, head CT and chest CT, with up to 130 findings on head CT (vendor figure).

Pearl
by Pearl Inc. · founded 2019
FDA-cleared dental x-ray AI (Second Opinion) that marks caries, bone loss and restorations, for dentists and DSOs.
When to pick each one
Harrison.ai
- Chest X-ray, head CT and chest CT reading
- Nine openFDA decisions, press says twelve
- Returns DICOM Secondary Capture to PACS
Pearl
- Dental bitewing, periapical and panoramic radiographs
- Eight openFDA decisions, March 2022 to November 2025
Score
Each row shows points earned of points available under the published rubric.
Harrison.ai
35of 100
Pearl
33of 100
| Dimension | Harrison.ai | Pearl | Difference |
|---|---|---|---|
| FDA clearance | 18 / 18 | 18 / 18 | 0 |
| HIPAA / SOC2 / BAA | 0 / 10 | 0 / 10 | 0 |
| EHR integrations (count) | 0 / 4.2 | 0 / 4.2 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 2.4 | 0 / 2.4 | 0 |
| Peer-reviewed papers | 0 / 18.2 | 0 / 18.2 | 0 |
| RCT / meta-analysis / systematic review | 0 / 7.8 | 0 / 7.8 | 0 |
| Funding & adoption signal | 8.4 / 12 | 3 / 12 | +5.4 |
| Pricing transparency | 2.5 / 5 | 2.5 / 5 | 0 |
| Years in market | 0 / 6 | 4.2 / 6 | -4.2 |
Scroll horizontally to see every column.
Pricing
Harrison.ai
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. Book a demo. |
Pearl
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Evidence
Harrison.ai
FDA decisions
K253818 (opens in new tab)510(k)2026-03-03
Annalise Enterprise (applicant Harrison-AI Medical Pty, Ltd.)
K250831 (opens in new tab)510(k)2025-04-23
Annalise Enterprise
K231767 (opens in new tab)510(k)2023-09-22
CTB Triage Trauma
K231384 (opens in new tab)510(k)2023-09-22
CTB Triage Trauma
K231094 (opens in new tab)510(k)2023-08-15
CTB Triage-OH
Show 4 more
K223240 (opens in new tab)510(k)2023-04-03
CTB Triage Trauma
K222268 (opens in new tab)510(k)2023-03-28
CXR Triage Trauma
K222179 (opens in new tab)510(k)2023-03-28
CXR Triage Trauma
K213941 (opens in new tab)510(k)2022-02-24
CXR Triage Pneumothorax
Pearl
FDA decisions
K250525 (opens in new tab)510(k)2025-11-14
Second Opinion Panoramic
K243234 (opens in new tab)510(k)2025-06-12
Second Opinion CS
K243989 (opens in new tab)510(k)2025-05-23
Second Opinion 3D
K243230 (opens in new tab)510(k)2025-05-09
Second Opinion BLE
K243893 (opens in new tab)510(k)2025-05-05
Second Opinion Pediatric
Show 3 more
K242600 (opens in new tab)510(k)2025-04-11
Second Opinion Periapical Radiolucency Contours
K242522 (opens in new tab)510(k)2025-01-16
Second Opinion CC
K210365 (opens in new tab)510(k)2022-03-04
Second Opinion
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Harrison.ai | Pearl |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | n/a | 2019 |
| HQ | AU | US |
Scroll horizontally to see both columns.
Common questions
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