icometrix vs Pearl
Dental x-rays and brain MRI go to different readers. Pearl's Second Opinion marks up to 18 findings per image on bitewing, periapical and panoramic films, including caries, bone loss and existing restorations. icobrain compares and quantifies brain MRI over time for radiologists and neurologists.
A general dentist or a DSO is Pearl's customer. The FAQ names DEXIS, Carestream, Romexis, Open Dental and Eaglesoft as integrations, and openFDA shows eight Second Opinion decisions, the earliest K210365 of March 4, 2022. The vendor says 29,000 practices on its home page and 23k+ on its About page.
A memory clinic or MS center tracking atrophy and lesion load is icometrix's customer. The vendor's reimbursement page has a blog on using the AMA CPT III codes 0865T and 0866T for icobrain.
Radiology · Reviewed November 2, 2026
When to pick each one
icometrix
- Brain MRI volumetry and lesion tracking over time
- AMA CPT III codes 0865T and 0866T for icobrain
Pearl
- Dental x-ray AI for dentists and DSOs
- Names DEXIS, Carestream and Open Dental integrations
- Eight Second Opinion decisions in openFDA
Score
Each row shows points earned of points available under the published rubric.
icometrix
68of 100
Pearl
33of 100
| Dimension | icometrix | Pearl | Difference |
|---|---|---|---|
| FDA clearance | 18 / 18 | 18 / 18 | 0 |
| HIPAA / SOC2 / BAA | 0 / 10 | 0 / 10 | 0 |
| EHR integrations (count) | 0 / 4.2 | 0 / 4.2 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 2.4 | 0 / 2.4 | 0 |
| Peer-reviewed papers | 18.2 / 18.2 | 0 / 18.2 | +18.2 |
| RCT / meta-analysis / systematic review | 3.9 / 7.8 | 0 / 7.8 | +3.9 |
| Funding & adoption signal | 8.4 / 12 | 3 / 12 | +5.4 |
| Pricing transparency | 2.5 / 5 | 2.5 / 5 | 0 |
| Years in market | 6 / 6 | 4.2 / 6 | +1.8 |
Scroll horizontally to see every column.
Pricing
icometrix
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Pearl
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Evidence
icometrix
FDA decisions
K240712 (opens in new tab)510(k)2024-11-07
icobrain aria
K192962 (opens in new tab)510(k)2020-02-28
icobrain-ctp
K192130 (opens in new tab)510(k)2019-12-13
Icobrain
K181939 (opens in new tab)510(k)2018-11-06
icobrain
K180326 (opens in new tab)510(k)2018-03-08
icobrain
Show 1 more
K161148 (opens in new tab)510(k)2016-08-09
icobrain
Peer-reviewed
5 PubMed records name icometrix.
- Lecanemab in practice: AI-derived MRI predictors of benefit and Amyloid Related Imaging Abnormalities (ARIA). (opens in new tab)
- Uncovering heterogeneous cognitive trajectories in relapsing-remitting multiple sclerosis: a longitudinal study. (opens in new tab)
- Quantifying White Matter Hyperintensities: Automated Volumetry Compared with Visual Grading Scales. (opens in new tab)
Pearl
FDA decisions
K250525 (opens in new tab)510(k)2025-11-14
Second Opinion Panoramic
K243234 (opens in new tab)510(k)2025-06-12
Second Opinion CS
K243989 (opens in new tab)510(k)2025-05-23
Second Opinion 3D
K243230 (opens in new tab)510(k)2025-05-09
Second Opinion BLE
K243893 (opens in new tab)510(k)2025-05-05
Second Opinion Pediatric
Show 3 more
K242600 (opens in new tab)510(k)2025-04-11
Second Opinion Periapical Radiolucency Contours
K242522 (opens in new tab)510(k)2025-01-16
Second Opinion CC
K210365 (opens in new tab)510(k)2022-03-04
Second Opinion
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | icometrix | Pearl |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | 2011 | 2019 |
| HQ | BE | US |
Scroll horizontally to see both columns.
Common questions
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Acute-care triage, mammography screening, CCTA plaque analysis, mobile MRI. 30+ FDA-cleared platforms across stroke, oncology, cardiac. Enterprise sales only — we compared what's deployed where.