MedAI Verdict
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Pearl vs ScreenPoint Transpara

A 2025 Diagnostics paper tested Second Opinion v1.1 and reported sensitivity of 91.0% for caries, 86.6% for periapical lesions, 80.2% for calculus and 91.1% for marginal bone loss, with caries specificity of 87%. That suits a dentist who wants a second reader on intraoral films. Pearl's own accuracy figures differ by page, 94% on the home page, validated by an unnamed third party, and over 95% in the FAQ.

Transpara goes to a group reading 2D and 3D mammograms, and Pearl goes to a dentist reading intraoral films. The MASAI screening trial is its evidence, and the vendor says Transpara was the tool. For the 2026 Lancet report the vendor cites a 12% lower interval cancer rate and sensitivity of 80.5% against 73.8% at 98.5% specificity across more than 105,000 women. The vendor's other headline figures, 29% more cancers detected and 44% less workload, come from separate analyses.

Radiology · Reviewed November 2, 2026

Pearl logo

Pearl

by Pearl Inc. · founded 2019

FDA-cleared dental x-ray AI (Second Opinion) that marks caries, bone loss and restorations, for dentists and DSOs.

ScreenPoint Transpara logo

ScreenPoint Transpara

by ScreenPoint Medical

Transpara Breast AI: cancer detection support, density and risk tools for 2D and 3D mammograms.

When to pick each one

Pearl

  • Caries sensitivity 91.0% in a 2025 study
  • Findings marked on bitewing and periapical films
  • Second Opinion Panoramic cleared, K250525
Read the full Pearl review

ScreenPoint Transpara

  • Detection on 2D and 3D mammograms
  • Eight Transpara 510(k)s since 2018
  • Randomized trial in screening, MASAI
Read the full ScreenPoint Transpara review

Score

Each row shows points earned of points available under the published rubric.

Pearl

33of 100

Competitive

ScreenPoint Transpara

56of 100

Solid choice
Score by dimension for Pearl and ScreenPoint Transpara
DimensionPearlScreenPoint TransparaDifference
FDA clearance18 / 1818 / 180
HIPAA / SOC2 / BAA0 / 100 / 100
EHR integrations (count)0 / 4.20 / 4.20
Top-3 EHR coverage (Epic / Oracle / Athena)0 / 2.40 / 2.40
Peer-reviewed papers0 / 18.212.7 / 18.2-12.7
RCT / meta-analysis / systematic review0 / 7.87.8 / 7.8-7.8
Funding & adoption signal3 / 126 / 12-3
Pricing transparency2.5 / 52.5 / 50
Years in market4.2 / 60 / 6+4.2

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How scores are computed

Pricing

Pearl

TierMonthlyAnnualNotes
Enterprisen/an/aNo public price.

ScreenPoint Transpara

TierMonthlyAnnualNotes
Enterprisen/an/aNo public price. Virtual demo and contact only.

Evidence

Pearl

FDA decisions

Show 3 more

Compliance and integrations

Documented from each vendor’s own pages.

SpecPearlScreenPoint Transpara
Free tierNo / unverifiedNo / unverified
HIPAANo / unverifiedNo / unverified
SOC 2 Type IINo / unverifiedNo / unverified
EHR integrationsNot specifiedNot specified
Founded2019n/a
HQUSNL

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Common questions

Open the full radiology comparison

Acute-care triage, mammography screening, CCTA plaque analysis, mobile MRI. 30+ FDA-cleared platforms across stroke, oncology, cardiac. Enterprise sales only — we compared what's deployed where.