Aidoc vs Pearl
openFDA shows 8 Second Opinion decisions, while Pearl's home page says "26+" clearances and the About page 26, with 29,000 practices on one page and 23k+ on the other. The vendor FAQ lists up to 18 findings, including incipient caries, bone loss and calculus, on bitewing, periapical and panoramic radiographs. The panoramic clearance (K250525) covers caries, periapical radiolucency and impacted third molars. A 2025 Diagnostics study of Second Opinion v1.1 reported 91.0% sensitivity for caries and 86.6% for periapical lesions. A 2026 Caries Research comparison of five commercial systems, Second Opinion among them, put secondary caries sensitivity between 0.327 and 0.487 across the five. The FAQ names DEXIS, Carestream, Romexis, Open Dental and Eaglesoft among 40+ integrations. Aidoc sells to hospital CT pulmonary angiography services, with a 2026 Radiology: AI study of its PE tool on more than 30,000 CTPA. Pearl's integration list is what a dental practice or DSO has to check, and that CTPA study is what a hospital PE pathway has to check.
Radiology · Reviewed November 2, 2026
Aidoc
by Aidoc · founded 2016
Clinical AI platform (aiOS) with FDA-cleared triage, notification and quantification algorithms for radiology and neurovascular care.
Pearl
by Pearl Inc. · founded 2019
FDA-cleared dental x-ray AI (Second Opinion) that marks caries, bone loss and restorations, for dentists and DSOs.
When to pick each one
Aidoc
- PE tool studied on 30,000 CTPA
- Hospital CT pulmonary angiography workflow
Pearl
- Vendor FAQ lists up to 18 findings
- 40+ integrations, Open Dental and Eaglesoft named
- Panoramic clearance K250525
Score
Each row shows points earned of points available under the published rubric.
Aidoc
71of 100
Pearl
33of 100
| Dimension | Aidoc | Pearl | Difference |
|---|---|---|---|
| FDA clearance | 18 / 18 | 18 / 18 | 0 |
| HIPAA / SOC2 / BAA | 0 / 10 | 0 / 10 | 0 |
| EHR integrations (count) | 0 / 4.2 | 0 / 4.2 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 2.4 | 0 / 2.4 | 0 |
| Peer-reviewed papers | 12.7 / 18.2 | 0 / 18.2 | +12.7 |
| RCT / meta-analysis / systematic review | 7.8 / 7.8 | 0 / 7.8 | +7.8 |
| Funding & adoption signal | 12 / 12 | 3 / 12 | +9 |
| Pricing transparency | 2.5 / 5 | 2.5 / 5 | 0 |
| Years in market | 6 / 6 | 4.2 / 6 | +1.8 |
Scroll horizontally to see every column.
Pricing
Aidoc
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Clinical AI Starter (AWS Marketplace) | n/a | n/a | Private offer only. No trial is stated. |
| Enterprise | n/a | n/a | No public price on aidoc.com. Quoted per module. |
Pearl
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Evidence
Aidoc
FDA decisions
K261317 (opens in new tab)510(k)2026-05-14
K253578 (opens in new tab)510(k)2026-02-26
CARE Multi-Triage CT
K251195 (opens in new tab)510(k)2026-01-27
K252970 (opens in new tab)510(k)2026-01-07
BriefCase-Triage: CARE Multi-triage CT Body
K253265 (opens in new tab)510(k)2025-11-06
Show 30 more
K251406 (opens in new tab)510(k)2025-05-30
K250248 (opens in new tab)510(k)2025-02-14
K243548 (opens in new tab)510(k)2024-12-11
K242203 (opens in new tab)510(k)2024-11-22
K242837 (opens in new tab)510(k)2024-10-18
K241727 (opens in new tab)510(k)2024-07-12
K241112 (opens in new tab)510(k)2024-05-15
K231631 (opens in new tab)510(k)2023-11-28
Quantification
K232083 (opens in new tab)510(k)2023-11-13
K230534 (opens in new tab)510(k)2023-11-08
K232751 (opens in new tab)510(k)2023-10-30
BriefCase-Triage
K230020 (opens in new tab)510(k)2023-02-01
K222692 (opens in new tab)510(k)2022-12-05
K221330 (opens in new tab)510(k)2022-11-18
K220709 (opens in new tab)510(k)2022-10-07
K222329 (opens in new tab)510(k)2022-09-28
K222277 (opens in new tab)510(k)2022-08-26
K221314 (opens in new tab)510(k)2022-06-03
K221240 (opens in new tab)510(k)2022-05-17
K213886 (opens in new tab)510(k)2022-04-26
K213721 (opens in new tab)510(k)2022-03-21
K214043 (opens in new tab)510(k)2022-03-14
K202992 (opens in new tab)510(k)2021-04-14
BriefCase RibFx
K203508 (opens in new tab)510(k)2020-12-29
K201020 (opens in new tab)510(k)2020-08-26
K193298 (opens in new tab)510(k)2020-06-19
K192383 (opens in new tab)510(k)2019-12-20
K190896 (opens in new tab)510(k)2019-05-31
K190072 (opens in new tab)510(k)2019-04-15
K180647 (opens in new tab)510(k)2018-08-01
BriefCase
Peer-reviewed
4 PubMed records name Aidoc.
- Transforming Stroke Diagnosis with Artificial Intelligence: A Scoping Review of Brainomix e-Stroke, Aidoc, RapidAI, and Viz.ai. (opens in new tab)
- Performance of FDA-Approved AI Algorithms in Detecting Acute Pulmonary Embolism on Computed Tomographic Pulmonary Angiography (CTPA): A Meta-Analysis of Real-World Retrospective Studies. (opens in new tab)
- Real-world performance evaluation of a commercial deep learning model for intracranial hemorrhage detection. (opens in new tab)
Pearl
FDA decisions
K250525 (opens in new tab)510(k)2025-11-14
Second Opinion Panoramic
K243234 (opens in new tab)510(k)2025-06-12
Second Opinion CS
K243989 (opens in new tab)510(k)2025-05-23
Second Opinion 3D
K243230 (opens in new tab)510(k)2025-05-09
Second Opinion BLE
K243893 (opens in new tab)510(k)2025-05-05
Second Opinion Pediatric
Show 3 more
K242600 (opens in new tab)510(k)2025-04-11
Second Opinion Periapical Radiolucency Contours
K242522 (opens in new tab)510(k)2025-01-16
Second Opinion CC
K210365 (opens in new tab)510(k)2022-03-04
Second Opinion
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Aidoc | Pearl |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | 2016 | 2019 |
| HQ | IL | US |
Scroll horizontally to see both columns.
Common questions
Open the full radiology comparison
Acute-care triage, mammography screening, CCTA plaque analysis, mobile MRI. 30+ FDA-cleared platforms across stroke, oncology, cardiac. Enterprise sales only — we compared what's deployed where.