Kardia 12L vs Zio
Kardia 12L derives a 12-lead tracing from five electrode placements on one cable. AliveCor announced new cardiac determinations in January 2026, bringing the total to 39, and a European launch in April 2026. Zio is a wear-and-send ECG patch service. The vendor says a deep neural network flags arrhythmias, cardiac technicians validate the findings and a physician report follows, and the bill goes to payers through Medicare-enrolled IDTFs.
A primary care clinic whose patient needs a tracing during the visit gets nothing from a patch worn at home and mailed back, so Zio loses there. A cardiology practice following a patient whose symptoms come and go over days refers for Zio, a service with no public price whose vendor says the algorithm is available in the US, EU, Switzerland, UK and Japan.
Decision support · Reviewed November 2, 2026

Kardia 12L
by AliveCor
Portable 12-lead ECG device with FDA-cleared AI interpretation, sold to clinicians with KardiaPro patient management access.
Zio
by iRhythm Technologies · founded 2006
Zio ECG patch service: a deep-learning algorithm flags arrhythmias, cardiac technicians validate them, and a physician report follows.
When to pick each one
Kardia 12L
- 12-lead derived from five electrode placements
- Vendor announced 39 FDA-cleared determinations
Zio
- Wear-and-send ECG patch with physician report
- Billed to payers through Medicare-enrolled IDTFs
Score
Each row shows points earned of points available under the published rubric.
Kardia 12L
38of 100
Zio
69of 100
| Dimension | Kardia 12L | Zio | Difference |
|---|---|---|---|
| FDA clearance | 12 / 12 | 12 / 12 | 0 |
| HIPAA / SOC2 / BAA | 10 / 10 | 0 / 10 | +10 |
| EHR integrations (count) | 0 / 5.6 | 0 / 5.6 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 4.8 | 0 / 4.8 | 0 |
| Bidirectional write-back | 0 / 1.2 | 0 / 1.2 | 0 |
| Peer-reviewed papers | 0 / 21 | 21 / 21 | -21 |
| RCT / meta-analysis / systematic review | 0 / 9 | 9 / 9 | -9 |
| Funding & adoption signal | 8.4 / 12 | 8.4 / 12 | 0 |
| Pricing transparency | 1.3 / 2.5 | 1.3 / 2.5 | 0 |
| Years in market | 0 / 6 | 6 / 6 | -6 |
Scroll horizontally to see every column.
Pricing
Kardia 12L
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Kardia 12L | n/a | n/a | Includes the device, KardiaStation app, KardiaPro access and a 3-year warranty, with a 90-day return policy. Two-week trial for eligible U.S. HCPs by form. The page does not state whether the price is one-time or recurring. |
Zio
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Evidence
Kardia 12L
FDA decisions
K252589 (opens in new tab)510(k)2026-01-09
Corvair Monza
K231010 (opens in new tab)510(k)2024-06-07
Corvair
K232035 (opens in new tab)510(k)2024-06-07
Impala
K220350 (opens in new tab)510(k)2022-05-25
KardiaMobile 6L
K212662 (opens in new tab)510(k)2022-04-26
AliveCor QT Service
Show 14 more
K211668 (opens in new tab)510(k)2021-11-30
KardiaMobile Card
K210753 (opens in new tab)510(k)2021-06-30
KardiaMobile 6L
K201985 (opens in new tab)510(k)2020-11-12
KardiaAI
K191406 (opens in new tab)510(k)2020-01-24
KardiaMobile, KardiaStation
K183319 (opens in new tab)510(k)2019-05-10
Triangle System
K181823 (opens in new tab)510(k)2019-04-12
KardiaAI
K182396 (opens in new tab)510(k)2019-04-12
KardiaMobile, KardiaStation
K171816 (opens in new tab)510(k)2017-11-16
Kardia Band System
K142743 (opens in new tab)510(k)2015-01-27
AliveCor Heart Monitor
K142672 (opens in new tab)510(k)2014-12-03
AliveCor Heart Monitor
K140933 (opens in new tab)510(k)2014-08-15
AliveCor Heart Monitor
K130921 (opens in new tab)510(k)2014-02-06
AliveCor Heart Monitor
K130409 (opens in new tab)510(k)2013-09-06
AliveCor Heart Monitor
K122356 (opens in new tab)510(k)2012-11-19
AliveCor Heart Monitor for iPhone
Zio
FDA decisions
K252859 (opens in new tab)510(k)2026-05-29
ZEUS Platform (FG0501US, DQK)
K243650 (opens in new tab)510(k)2025-08-15
Zio monitor (DFG0001)
K240177 (opens in new tab)510(k)2024-10-30
Zio AT device (A100A1001, DSI)
K240029 (opens in new tab)510(k)2024-10-21
Zio AT device (A100A1001, QYX)
K222389 (opens in new tab)510(k)2023-02-15
ZEUS System
Show 13 more
K213409 (opens in new tab)510(k)2022-07-19
ZEUS System (Zio Watch)
K202359 (opens in new tab)510(k)2021-05-21
Zio Monitor
K202527 (opens in new tab)510(k)2021-05-21
ZEUS System
K190593 (opens in new tab)510(k)2019-08-23
Zio XT ECG Monitoring System, Zio AT
K181502 (opens in new tab)510(k)2018-08-29
Zio AT ECG Monitoring System, ZEUS System
K163512 (opens in new tab)510(k)2017-06-02
Zio AT ECG Monitoring System
K143513 (opens in new tab)510(k)2015-06-19
ZIO SR ECG Monitoring Service
K142681 (opens in new tab)510(k)2014-11-21
ZEUS System
K121319 (opens in new tab)510(k)2012-07-18
ZIO PATCH
K113862 (opens in new tab)510(k)2012-02-06
ZIO PATCH
K091075 (opens in new tab)510(k)2009-07-21
ZEUS (ZIO ECG UTILIZATION SERVICE) SYSTEM
K090363 (opens in new tab)510(k)2009-05-08
ZIO PATCH Z100
K081471 (opens in new tab)510(k)2008-06-24
ECARD AND CCARD
Peer-reviewed
5 PubMed records name Zio.
- Physical activity cut-points for older adults using the Zio XT onboard accelerometer. (opens in new tab)
- Validation of a Zio XT Patch Accelerometer for the Objective Assessment of Physical Activity in the Atherosclerosis Risk in Communities (ARIC) Study. (opens in new tab)
- Zio® XT Patches in Pediatrics During the COVID-19 Pandemic: Comparisons Between In-Person and Mail-Home Application. (opens in new tab)
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Kardia 12L | Zio |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | n/a | 2006 |
| HQ | US | US |
Scroll horizontally to see both columns.
Common questions
Open the full decision support comparison
Differential diagnosis, treatment guidance, drug interactions, evidence-grounded Q&A. The CDS landscape ranges from the UpToDate gold standard to physician-only OpenEvidence. We compared what clinicians actually use.
