OpenEvidence vs UpToDate Expert AI
OpenEvidence and UpToDate Expert AI both compete in decision support, but answer different questions. OpenEvidence is our pick for physician Q&A: Used by ~65% of US physicians for grounded clinical questions. UpToDate Expert AI earns the CDS standard slot: The global institutional CDS reference, now with grounded generative Q&A. The right choice depends on whether your priority is physician q&a or cds standard.
- Decision support
- 02
- May 23, 2026
OpenEvidence
by OpenEvidence · founded 2022
Free physician-only literature-grounded Q&A, 1M consults/day.
- Free for NPI-verified physicians (ad-funded).
- —
UpToDate Expert AI
by Wolters Kluwer
Gold-standard curated CDS with generative AI layer.
- ~$559/year individual + Enterprise.
- HIPAA
How OpenEvidence and UpToDate Expert AI compare
Pricing, compliance, and integrations sourced from vendor documentation. Verified May 23, 2026.
| Spec | OpenEvidence | UpToDate Expert AI |
|---|---|---|
| Pricing | Free for NPI-verified physicians (ad-funded). | ~$559/year individual + Enterprise. |
| Free tier | Yes | Yes |
| HIPAA | No / unverified | Yes |
| SOC 2 Type II | No / unverified | No / unverified |
| EHR integrations | Not specified | Not specified |
| Founded | 2022 | — |
| HQ | US | NL |
| Best for | Best free physician Q&A | Best institutional CDS standard |
Scroll horizontally to see both columns.
When to pick each one
Best free physician Q&A
Used by ~65% of US physicians for grounded clinical questions.
- Free for NPI-verified physicians
- Pharma-ad funded
- Every answer is literature-traceable
- Embedded in Mt Sinai Epic
Best institutional CDS standard
The global institutional CDS reference, now with grounded generative Q&A.
- $559/year individual or institutional licensing
- Awards CME credit for queries (March 2026)
- Wolters Kluwer
Open the full decision support comparison
Differential diagnosis, treatment guidance, drug interactions, evidence-grounded Q&A. The CDS landscape ranges from the UpToDate gold standard to physician-only OpenEvidence. We compared what clinicians actually use.
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