Kardia 12L vs Isabel Healthcare
Kardia 12L is hardware for a cardiology office that wants tracings stored and reviewed in KardiaPro, with a two-week trial for eligible U.S. clinicians and a 90-day return policy. Isabel DDx Companion is a software subscription, and no clinic substitutes one for the other.
An internist or emergency physician who wants a ranked differential with red-flag diagnoses and a medication-cause check is Isabel's customer. The vendor says the tool is in the Cerner App Gallery and that Epic clients can have info-button access, and it claims the correct disease lands in the top ten with 96% accuracy. A 2025 study of 100 rare-disease patients, set against an interdisciplinary case conference, reported a top-ten match to at least one conference diagnosis in 28% (per a summary of the study). An older UK teaching-hospital series reported 83 of 87 cases correct, secondhand. Standard costs $149 per year, Premium $199, and the student and resident rate is $49 per year.
Decision support · Reviewed November 2, 2026
Kardia 12L
by AliveCor
Portable 12-lead ECG device with FDA-cleared AI interpretation, sold to clinicians with KardiaPro patient management access.
Isabel Healthcare
by Isabel Healthcare · founded 1999
Differential-diagnosis generator with self-triage and educator products. The vendor says it is used in over 90 countries and 14 languages.
When to pick each one
Kardia 12L
- Two-week trial for eligible U.S. clinicians
- 90-day return policy
- KardiaPro access for review and storage
Isabel Healthcare
- Standard $149 per year, Premium $199 per year
- Vendor-stated Cerner App Gallery listing
- $49 per year for students and residents
Score
Each row shows points earned of points available under the published rubric.
Kardia 12L
38of 100
Isabel Healthcare
35of 100
| Dimension | Kardia 12L | Isabel Healthcare | Difference |
|---|---|---|---|
| FDA clearance | 12 / 12 | 0 / 12 | +12 |
| HIPAA / SOC2 / BAA | 10 / 10 | 0 / 10 | +10 |
| EHR integrations (count) | 0 / 5.6 | 0 / 5.6 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 4.8 | 0 / 4.8 | 0 |
| Bidirectional write-back | 0 / 1.2 | 0 / 1.2 | 0 |
| Peer-reviewed papers | 0 / 21 | 14.7 / 21 | -14.7 |
| RCT / meta-analysis / systematic review | 0 / 9 | 0 / 9 | 0 |
| Funding & adoption signal | 8.4 / 12 | 6 / 12 | +2.4 |
| Pricing transparency | 1.3 / 2.5 | 2.5 / 2.5 | -1.2 |
| Years in market | 0 / 6 | 6 / 6 | -6 |
Scroll horizontally to see every column.
Pricing
Kardia 12L
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Kardia 12L | n/a | n/a | Includes the device, KardiaStation app, KardiaPro access and a 3-year warranty, with a 90-day return policy. Two-week trial for eligible U.S. HCPs by form. The page does not state whether the price is one-time or recurring. |
Isabel Healthcare
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Standard | n/a | $149 | EUR 139 incl. VAT. 30-day free trial. |
| Premium | n/a | $199 | EUR 179 incl. VAT. Adds an LLM layer (English only). |
| Student / resident | n/a | $49 | Not available to EU students. 50% discount for listed emerging economies. |
| Institutional | n/a | n/a | Demo request, no public price. The API has been available since 2010. |
Evidence
Kardia 12L
FDA decisions
K252589 (opens in new tab)510(k)2026-01-09
Corvair Monza
K231010 (opens in new tab)510(k)2024-06-07
Corvair
K232035 (opens in new tab)510(k)2024-06-07
Impala
K220350 (opens in new tab)510(k)2022-05-25
KardiaMobile 6L
K212662 (opens in new tab)510(k)2022-04-26
AliveCor QT Service
Show 14 more
K211668 (opens in new tab)510(k)2021-11-30
KardiaMobile Card
K210753 (opens in new tab)510(k)2021-06-30
KardiaMobile 6L
K201985 (opens in new tab)510(k)2020-11-12
KardiaAI
K191406 (opens in new tab)510(k)2020-01-24
KardiaMobile, KardiaStation
K183319 (opens in new tab)510(k)2019-05-10
Triangle System
K181823 (opens in new tab)510(k)2019-04-12
KardiaAI
K182396 (opens in new tab)510(k)2019-04-12
KardiaMobile, KardiaStation
K171816 (opens in new tab)510(k)2017-11-16
Kardia Band System
K142743 (opens in new tab)510(k)2015-01-27
AliveCor Heart Monitor
K142672 (opens in new tab)510(k)2014-12-03
AliveCor Heart Monitor
K140933 (opens in new tab)510(k)2014-08-15
AliveCor Heart Monitor
K130921 (opens in new tab)510(k)2014-02-06
AliveCor Heart Monitor
K130409 (opens in new tab)510(k)2013-09-06
AliveCor Heart Monitor
K122356 (opens in new tab)510(k)2012-11-19
AliveCor Heart Monitor for iPhone
Isabel Healthcare
FDA decisions
No FDA decision cited in our research as of October 20, 2026.
Peer-reviewed
2 PubMed records name Isabel Healthcare.
- Cracking the code: a head-to-head comparison of expert clinicians and artificial intelligence in diagnosing rare diseases. (opens in new tab)
- Is language an issue? Accuracy of the German computerized diagnostic decision support system ISABEL and cross-validation with the English counterpart. (opens in new tab)
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Kardia 12L | Isabel Healthcare |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | n/a | 1999 |
| HQ | US | UK |
Scroll horizontally to see both columns.
Common questions
Open the full decision support comparison
Differential diagnosis, treatment guidance, drug interactions, evidence-grounded Q&A. The CDS landscape ranges from the UpToDate gold standard to physician-only OpenEvidence. We compared what clinicians actually use.