Anumana vs Epic Sepsis Model
The Epic Sepsis Model scores adult inpatients and ED patients inside the EHR every 15 minutes, with alert thresholds set by each hospital and no separate published price. Michigan Medicine's 2021 validation of 38,455 hospitalizations found an AUROC of 0.63 and 67% of sepsis cases missed. A 2026 prospective study across four US systems tested the updated version and reported AUROC 0.82 to 0.92 with a positive predictive value of 0.13 to 0.26. openFDA lists no clearance for the Epic Sepsis Model, and K260008 covers Epic's separate Deterioration Index.
Anumana's buyer is a health system's cardiology department. The company's ECG-AI algorithms for low ejection fraction, pulmonary hypertension and cardiac amyloidosis each went through FDA 510(k) clearance, and they read standard 12-lead ECGs. Epic's model is delivered within the Epic license to hospitals that want a sepsis alert. A hospital that requires an FDA clearance before switching an alert on has to look at another sepsis tool.
Decision support · Reviewed November 2, 2026
Anumana
by Anumana
ECG-AI software that flags low ejection fraction, pulmonary hypertension and cardiac amyloidosis from standard 12-lead ECGs.
Epic Sepsis Model
by Epic Systems
Sepsis risk score calculated every 15 minutes inside the Epic EHR, with alert thresholds set by each hospital.
When to pick each one
Anumana
- Three ECG-AI conditions, each FDA-cleared
- Runs on standard 12-lead ECGs
Epic Sepsis Model
- Built into Epic, delivered within Epic licensing
- Validated in four US health systems in 2026
Score
Each row shows points earned of points available under the published rubric.
Anumana
37of 100
Epic Sepsis Model
41of 100
| Dimension | Anumana | Epic Sepsis Model | Difference |
|---|---|---|---|
| FDA clearance | 12 / 12 | 0 / 12 | +12 |
| HIPAA / SOC2 / BAA | 0 / 10 | 0 / 10 | 0 |
| EHR integrations (count) | 0 / 5.6 | 0 / 5.6 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 4.8 | 0 / 4.8 | 0 |
| Bidirectional write-back | 0 / 1.2 | 0 / 1.2 | 0 |
| Peer-reviewed papers | 14.7 / 21 | 21 / 21 | -6.3 |
| RCT / meta-analysis / systematic review | 0 / 9 | 9 / 9 | -9 |
| Funding & adoption signal | 3 / 12 | 3 / 12 | 0 |
| Pricing transparency | 1.3 / 2.5 | 1.3 / 2.5 | 0 |
| Years in market | 0 / 6 | 0 / 6 | 0 |
Scroll horizontally to see every column.
Pricing
Anumana
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. The pricing page returns 404; the site offers a demo request only. |
Epic Sepsis Model
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. Delivered within Epic licensing. |
Evidence
Anumana
FDA decisions
K253801 (opens in new tab)510(k)2026-04-07
ECG-AI Cardiac Amyloidosis (CA) 12-Lead Algorithm (1040)
K252360 (opens in new tab)510(k)2026-03-28
ECG-AI Pulmonary Hypertension (PH) 12-Lead algorithm (1020)
K250652 (opens in new tab)510(k)2025-07-28
ECG-AI Low Ejection Fraction (LEF) 12-Lead algorithm (1010)
K232699 (opens in new tab)510(k)2023-09-28
Low Ejection Fraction AI-ECG Algorithm
Peer-reviewed
3 PubMed records name Anumana.
- A Pragmatic Trial Evaluating the Impact of the Anumana Clinical Decision Support Tool for Guideline-Directed Management of Heart Failure (ACT-HF): Clinical trial design and methods. (opens in new tab)
- Comment on "A pragmatic trial evaluating the impact of the anumana clinical decision support tool for guideline-directed management of heart failure (ACT-HF): Clinical trial design and methods". (opens in new tab)
- Identification and risk stratification of coronary disease by artificial intelligence-enabled ECG. (opens in new tab)
Epic Sepsis Model
FDA decisions
No FDA decision cited in our research as of November 2, 2026.
Peer-reviewed
5 PubMed records name Epic Sepsis Model.
- A Systematic Review and Meta-analysis of Externally Validated Epic Clinical Decision Support Tools. (opens in new tab)
- Evaluation of Sepsis Prediction Models before Onset of Treatment. (opens in new tab)
- Multicenter Prospective Validation of an Updated Proprietary Sepsis Prediction Model. (opens in new tab)
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Anumana | Epic Sepsis Model |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | n/a | n/a |
| HQ | US | US |
Scroll horizontally to see both columns.
Common questions
Open the full decision support comparison
Differential diagnosis, treatment guidance, drug interactions, evidence-grounded Q&A. The CDS landscape ranges from the UpToDate gold standard to physician-only OpenEvidence. We compared what clinicians actually use.