Anumana vs Isabel Healthcare
Isabel is the one with a price a physician can read. DDx Companion costs $149 per year on Standard and $199 on Premium, $49 for students and residents, with a 30-day free trial. It turns demographics and symptoms into a ranked differential with red-flag diagnoses. The vendor reports 96% accuracy for the correct disease appearing in the top ten and says it covers over 10,000 conditions. A 2025 head-to-head of 100 rare-disease patients against an interdisciplinary case conference found its top ten matched at least one conference diagnosis in 28%, and the authors say history filtering may limit standalone effectiveness. Institutions can reach it through the Cerner App Gallery, an Epic info button or an API.
Anumana started in 2021 as a joint venture of Mayo Clinic and nference. Its ECG-AI for low ejection fraction, pulmonary hypertension and cardiac amyloidosis is bought by a cardiology service or a health system, on a demo request with no published price.
An internist paying $149 a year and a cardiology buyer are shopping for different things.
Decision support · Reviewed November 2, 2026
Anumana
by Anumana
ECG-AI software that flags low ejection fraction, pulmonary hypertension and cardiac amyloidosis from standard 12-lead ECGs.
Isabel Healthcare
by Isabel Healthcare · founded 1999
Differential-diagnosis generator with self-triage and educator products. The vendor says it is used in over 90 countries and 14 languages.
When to pick each one
Anumana
- Cleared ECG-AI for low EF, PH and amyloidosis
- Flags from 12-lead ECGs already recorded
Isabel Healthcare
- $149 per year Standard, $199 Premium
- 30-day free trial
Score
Each row shows points earned of points available under the published rubric.
Anumana
37of 100
Isabel Healthcare
35of 100
| Dimension | Anumana | Isabel Healthcare | Difference |
|---|---|---|---|
| FDA clearance | 12 / 12 | 0 / 12 | +12 |
| HIPAA / SOC2 / BAA | 0 / 10 | 0 / 10 | 0 |
| EHR integrations (count) | 0 / 5.6 | 0 / 5.6 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 4.8 | 0 / 4.8 | 0 |
| Bidirectional write-back | 0 / 1.2 | 0 / 1.2 | 0 |
| Peer-reviewed papers | 14.7 / 21 | 14.7 / 21 | 0 |
| RCT / meta-analysis / systematic review | 0 / 9 | 0 / 9 | 0 |
| Funding & adoption signal | 3 / 12 | 6 / 12 | -3 |
| Pricing transparency | 1.3 / 2.5 | 2.5 / 2.5 | -1.2 |
| Years in market | 0 / 6 | 6 / 6 | -6 |
Scroll horizontally to see every column.
Pricing
Anumana
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. The pricing page returns 404; the site offers a demo request only. |
Isabel Healthcare
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Standard | n/a | $149 | EUR 139 incl. VAT. 30-day free trial. |
| Premium | n/a | $199 | EUR 179 incl. VAT. Adds an LLM layer (English only). |
| Student / resident | n/a | $49 | Not available to EU students. 50% discount for listed emerging economies. |
| Institutional | n/a | n/a | Demo request, no public price. The API has been available since 2010. |
Evidence
Anumana
FDA decisions
K253801 (opens in new tab)510(k)2026-04-07
ECG-AI Cardiac Amyloidosis (CA) 12-Lead Algorithm (1040)
K252360 (opens in new tab)510(k)2026-03-28
ECG-AI Pulmonary Hypertension (PH) 12-Lead algorithm (1020)
K250652 (opens in new tab)510(k)2025-07-28
ECG-AI Low Ejection Fraction (LEF) 12-Lead algorithm (1010)
K232699 (opens in new tab)510(k)2023-09-28
Low Ejection Fraction AI-ECG Algorithm
Peer-reviewed
3 PubMed records name Anumana.
- A Pragmatic Trial Evaluating the Impact of the Anumana Clinical Decision Support Tool for Guideline-Directed Management of Heart Failure (ACT-HF): Clinical trial design and methods. (opens in new tab)
- Comment on "A pragmatic trial evaluating the impact of the anumana clinical decision support tool for guideline-directed management of heart failure (ACT-HF): Clinical trial design and methods". (opens in new tab)
- Identification and risk stratification of coronary disease by artificial intelligence-enabled ECG. (opens in new tab)
Isabel Healthcare
FDA decisions
No FDA decision cited in our research as of October 20, 2026.
Peer-reviewed
2 PubMed records name Isabel Healthcare.
- Cracking the code: a head-to-head comparison of expert clinicians and artificial intelligence in diagnosing rare diseases. (opens in new tab)
- Is language an issue? Accuracy of the German computerized diagnostic decision support system ISABEL and cross-validation with the English counterpart. (opens in new tab)
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Anumana | Isabel Healthcare |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | n/a | 1999 |
| HQ | US | UK |
Scroll horizontally to see both columns.
Common questions
Open the full decision support comparison
Differential diagnosis, treatment guidance, drug interactions, evidence-grounded Q&A. The CDS landscape ranges from the UpToDate gold standard to physician-only OpenEvidence. We compared what clinicians actually use.