Bayesian Health vs Epic Sepsis Model
openFDA's 510(k) record lists K250680, a Class II clearance dated April 30, 2026, for Bayesian Health's sepsis flag and lists no clearance for the Epic Sepsis Model. Epic holds K260008, which covers a different model, the Deterioration Index Version 2.
Michigan Medicine's 38,455 hospitalizations gave the first version an AUROC of 0.63, with 67% of sepsis cases missed while 18% of hospitalizations drew an alert. The updated version reached 0.82 to 0.92 across four systems in a 2026 prospective validation, with positive predictive value of 0.13 to 0.26 and a high alert burden. The only alert-volume figure for Bayesian is the vendor's homepage claim of alerts 20 times fewer than Epic's algorithm at one customer, and it is unverified.
An Epic hospital that wants a score delivered within its existing license has a reason to stay put. For a sepsis committee weighing a published positive predictive value of 0.13 to 0.26, the Epic model is the weaker pick on the evidence it has.
Decision support · Reviewed November 2, 2026
Bayesian Health
by Bayesian Health
Sepsis flagging software that monitors EHR data continuously and shows a high-risk flag in the chart. FDA 510(k) cleared April 2026.
Epic Sepsis Model
by Epic Systems
Sepsis risk score calculated every 15 minutes inside the Epic EHR, with alert thresholds set by each hospital.
When to pick each one
Bayesian Health
- FDA 510(k) K250680, Class II, cleared April 2026
- Vendor says alert volume 20x below Epic's at one customer
- Five-hospital Nature Medicine study of the TREWS lineage
Epic Sepsis Model
- Native to the Epic EHR, score every 15 minutes
- Delivered within Epic licensing
- Version 2 can be localized to a hospital
Score
Each row shows points earned of points available under the published rubric.
Bayesian Health
33of 100
Epic Sepsis Model
41of 100
| Dimension | Bayesian Health | Epic Sepsis Model | Difference |
|---|---|---|---|
| FDA clearance | 12 / 12 | 0 / 12 | +12 |
| HIPAA / SOC2 / BAA | 0 / 10 | 0 / 10 | 0 |
| EHR integrations (count) | 0 / 5.6 | 0 / 5.6 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 4.8 | 0 / 4.8 | 0 |
| Bidirectional write-back | 0 / 1.2 | 0 / 1.2 | 0 |
| Peer-reviewed papers | 8.4 / 21 | 21 / 21 | -12.6 |
| RCT / meta-analysis / systematic review | 0 / 9 | 9 / 9 | -9 |
| Funding & adoption signal | 6 / 12 | 3 / 12 | +3 |
| Pricing transparency | 1.3 / 2.5 | 1.3 / 2.5 | 0 |
| Years in market | 0 / 6 | 0 / 6 | 0 |
Scroll horizontally to see every column.
Pricing
Bayesian Health
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Epic Sepsis Model
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. Delivered within Epic licensing. |
Evidence
Bayesian Health
FDA decisions
K250680 (opens in new tab)510(k)2026-04-30
Bayesian Health Sepsis Flagging Device
Peer-reviewed
1 PubMed record names Bayesian Health.
Epic Sepsis Model
FDA decisions
No FDA decision cited in our research as of November 2, 2026.
Peer-reviewed
5 PubMed records name Epic Sepsis Model.
- A Systematic Review and Meta-analysis of Externally Validated Epic Clinical Decision Support Tools. (opens in new tab)
- Evaluation of Sepsis Prediction Models before Onset of Treatment. (opens in new tab)
- Multicenter Prospective Validation of an Updated Proprietary Sepsis Prediction Model. (opens in new tab)
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Bayesian Health | Epic Sepsis Model |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | n/a | n/a |
| HQ | US | US |
Scroll horizontally to see both columns.
Common questions
Open the full decision support comparison
Differential diagnosis, treatment guidance, drug interactions, evidence-grounded Q&A. The CDS landscape ranges from the UpToDate gold standard to physician-only OpenEvidence. We compared what clinicians actually use.