C8 Health vs Epic Sepsis Model
openFDA lists no record for C8 Health or the Epic Sepsis Model. Epic's one clearance, K260008 from September 2026, covers Deterioration Index Version 2, a different model.
Several independent studies cover the Epic Sepsis Model. A 2021 JAMA Internal Medicine study of 38,455 hospitalizations at Michigan Medicine found a hospitalization-level AUROC of 0.63, with 67% of sepsis cases missed and alerts on 18% of hospitalizations. An emergency department study of 35,076 encounters in the American Journal of Emergency Medicine (2025) found AUROC 0.77 for version 1 and 0.90 for version 2. A 2026 multicentre prospective study of version 2 across four systems still reported PPV of 0.13 to 0.26 and a high alert burden. C8's one PubMed paper is a 2026 usability survey of 142 MetroHealth anesthesiology clinicians, co-written by C8's chief medical officer. Its outcome figures come from the vendor's proof library.
An Epic hospital's sepsis committee gets the score inside the EHR, delivered within Epic licensing. C8 Health, which calls itself a care consistency platform, is sold separately to health systems with no public price.
Decision support · Reviewed November 2, 2026
C8 Health
by C8 Health Inc. · founded 2019
Protocol knowledge platform for hospitals, with an AI assistant that answers only from the hospital's vetted content.
Epic Sepsis Model
by Epic Systems
Sepsis risk score calculated every 15 minutes inside the Epic EHR, with alert thresholds set by each hospital.
When to pick each one
C8 Health
- Care consistency platform for health systems
- Contact for a quote, no public price
Epic Sepsis Model
- Score runs inside the Epic EHR
- Delivered within Epic licensing
- Version 2 can be localized per hospital
Score
Each row shows points earned of points available under the published rubric.
C8 Health
32of 100
Epic Sepsis Model
41of 100
| Dimension | C8 Health | Epic Sepsis Model | Difference |
|---|---|---|---|
| FDA clearance | 0 / 12 | 0 / 12 | 0 |
| HIPAA / SOC2 / BAA | 10 / 10 | 0 / 10 | +10 |
| EHR integrations (count) | 0 / 5.6 | 0 / 5.6 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 4.8 | 0 / 4.8 | 0 |
| Bidirectional write-back | 0 / 1.2 | 0 / 1.2 | 0 |
| Peer-reviewed papers | 8.4 / 21 | 21 / 21 | -12.6 |
| RCT / meta-analysis / systematic review | 0 / 9 | 9 / 9 | -9 |
| Funding & adoption signal | 3 / 12 | 3 / 12 | 0 |
| Pricing transparency | 1.3 / 2.5 | 1.3 / 2.5 | 0 |
| Years in market | 4.2 / 6 | 0 / 6 | +4.2 |
Scroll horizontally to see every column.
Pricing
C8 Health
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Epic Sepsis Model
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. Delivered within Epic licensing. |
Evidence
C8 Health
FDA decisions
No FDA decision cited in our research as of November 2, 2026.
Peer-reviewed
1 PubMed record names C8 Health.
Epic Sepsis Model
FDA decisions
No FDA decision cited in our research as of November 2, 2026.
Peer-reviewed
5 PubMed records name Epic Sepsis Model.
- A Systematic Review and Meta-analysis of Externally Validated Epic Clinical Decision Support Tools. (opens in new tab)
- Evaluation of Sepsis Prediction Models before Onset of Treatment. (opens in new tab)
- Multicenter Prospective Validation of an Updated Proprietary Sepsis Prediction Model. (opens in new tab)
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | C8 Health | Epic Sepsis Model |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | 2019 | n/a |
| HQ | US | US |
Scroll horizontally to see both columns.
Common questions
Open the full decision support comparison
Differential diagnosis, treatment guidance, drug interactions, evidence-grounded Q&A. The CDS landscape ranges from the UpToDate gold standard to physician-only OpenEvidence. We compared what clinicians actually use.