Ceribell vs Epic Sepsis Model

Ceribell is bought for point-of-care EEG with AI seizure detection and a delirium monitor by ICUs and emergency departments. The vendor says the seizure detection covers all ages, from 25-week preterm neonates through adults. openFDA lists 16 Ceribell records, all substantially equivalent, and 29 PubMed papers name Ceribell.

The Epic model is a sepsis risk score inside the EHR for hospitals that license Epic, with alert thresholds the hospital sets. It does not compete with an EEG recorder. An external validation of version 1 at Michigan Medicine (Wong et al., JAMA Internal Medicine, 2021) covered 38,455 hospitalizations and found a hospitalization-level AUROC of 0.63, with 67 percent of sepsis cases missed while 18 percent of hospitalizations drew an alert. A multicenter prospective validation of version 2 in four US systems (Wong et al., JAMA Network Open, 2026) found encounter-level AUROC of 0.82 to 0.92 and positive predictive value of 0.13 to 0.26, with high institutional variability and a high alert burden.