Epic Sepsis Model vs PERISCOPE
The vendor says PERISCOPE gives surgical departments a 7-day and 30-day infection risk from existing EHR data, is CE-marked as a Class IIa device under EU MDR, holds ISO 13485 and ISO 27001, and typically takes 8 to 12 weeks to implement. openFDA holds no Healthplus.ai or PERISCOPE record, and no price is public. The published support is a Lancet Regional Health Europe paper on 253,010 procedures at three hospitals in the Netherlands and Belgium, with 30-day AUROCs of 0.82, 0.82 and 0.91 on temporal validation. Two authors work at Healthplus.ai, and the design was retrospective.
Because one tool predicts infection after surgery and the other flags sepsis onset, a surgical department and an Epic hospital's inpatient units do not buy the same thing. A hospital already on Epic licenses the sepsis model within the EHR for adult inpatients and ED patients, rescored every 15 minutes with alert thresholds the hospital sets.
Decision support · Reviewed November 2, 2026
Epic Sepsis Model
by Epic Systems
Sepsis risk score calculated every 15 minutes inside the Epic EHR, with alert thresholds set by each hospital.
PERISCOPE
by Healthplus.ai
PERISCOPE predicts postoperative bacterial infection risk 7 and 30 days after surgery from EHR data.
When to pick each one
Epic Sepsis Model
- Scores every 15 minutes inside the Epic EHR
- Hospital sets its own alert thresholds
PERISCOPE
- Infection risk at 7 and 30 days after surgery
- CE-marked Class IIa, per the vendor
Score
Each row shows points earned of points available under the published rubric.
Epic Sepsis Model
41of 100
PERISCOPE
15of 100
| Dimension | Epic Sepsis Model | PERISCOPE | Difference |
|---|---|---|---|
| FDA clearance | 0 / 12 | 0 / 12 | 0 |
| HIPAA / SOC2 / BAA | 0 / 10 | 0 / 10 | 0 |
| EHR integrations (count) | 0 / 5.6 | 0 / 5.6 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 4.8 | 0 / 4.8 | 0 |
| Bidirectional write-back | 0 / 1.2 | 0 / 1.2 | 0 |
| Peer-reviewed papers | 21 / 21 | 8.4 / 21 | +12.6 |
| RCT / meta-analysis / systematic review | 9 / 9 | 0 / 9 | +9 |
| Funding & adoption signal | 3 / 12 | 3 / 12 | 0 |
| Pricing transparency | 1.3 / 2.5 | 1.3 / 2.5 | 0 |
| Years in market | 0 / 6 | 0 / 6 | 0 |
Scroll horizontally to see every column.
Pricing
Epic Sepsis Model
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. Delivered within Epic licensing. |
PERISCOPE
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Evidence
Epic Sepsis Model
FDA decisions
No FDA decision cited in our research as of November 2, 2026.
Peer-reviewed
5 PubMed records name Epic Sepsis Model.
- A Systematic Review and Meta-analysis of Externally Validated Epic Clinical Decision Support Tools. (opens in new tab)
- Evaluation of Sepsis Prediction Models before Onset of Treatment. (opens in new tab)
- Multicenter Prospective Validation of an Updated Proprietary Sepsis Prediction Model. (opens in new tab)
PERISCOPE
FDA decisions
No FDA decision cited in our research as of November 2, 2026.
Peer-reviewed
1 PubMed record names PERISCOPE.
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Epic Sepsis Model | PERISCOPE |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | n/a | n/a |
| HQ | US | NL |
Scroll horizontally to see both columns.
Common questions
Open the full decision support comparison
Differential diagnosis, treatment guidance, drug interactions, evidence-grounded Q&A. The CDS landscape ranges from the UpToDate gold standard to physician-only OpenEvidence. We compared what clinicians actually use.