Epic Sepsis Model vs SimpleSense
Nanowear holds four 510(k) clearances, the latest K232053 for SimpleSense-BP, which estimates blood pressure without a cuff. It sells a cloth garment for heart failure and blood pressure monitoring at home. A prospective internal validation of SimpleSense-BP by Nanowear authors covered 303 subjects over four weeks, and they ask for external validation. The homepage lists no price. Its customer is a cardiology clinic that sends outpatients home wearing it.
The Epic Sepsis Model is a risk score for adult inpatients and ED patients, shown as an alert inside Epic. A 2021 JAMA Internal Medicine validation at Michigan Medicine covered 38,455 hospitalizations. Hospitalization-level AUROC was 0.63, and the model missed 67% of sepsis cases while alerting on 18% of hospitalizations. Epic hospitals get it within Epic licensing, and its pricing is not stated.
An Epic hospital runs the sepsis score on its inpatient wards, while a heart failure program issues the garment to patients at home, so the two sit in different care settings.
Decision support · Reviewed November 2, 2026
Epic Sepsis Model
by Epic Systems
Sepsis risk score calculated every 15 minutes inside the Epic EHR, with alert thresholds set by each hospital.
SimpleSense
by Nanowear · founded 2014
Cloth wearable with 510(k) cleared AI cloud analytics for remote cardiac monitoring and cuffless blood pressure.
When to pick each one
Epic Sepsis Model
- Native to Epic, no separate integration
- Covers adult inpatients and ED patients
- Delivered within Epic licensing
SimpleSense
- Four 510(k) clearances, latest K232053
- Cuffless blood pressure with SimpleSense-BP
- Wearable garment for home monitoring
Score
Each row shows points earned of points available under the published rubric.
Epic Sepsis Model
41of 100
SimpleSense
49of 100
| Dimension | Epic Sepsis Model | SimpleSense | Difference |
|---|---|---|---|
| FDA clearance | 0 / 12 | 12 / 12 | -12 |
| HIPAA / SOC2 / BAA | 0 / 10 | 0 / 10 | 0 |
| EHR integrations (count) | 0 / 5.6 | 0 / 5.6 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 4.8 | 0 / 4.8 | 0 |
| Bidirectional write-back | 0 / 1.2 | 0 / 1.2 | 0 |
| Peer-reviewed papers | 21 / 21 | 14.7 / 21 | +6.3 |
| RCT / meta-analysis / systematic review | 9 / 9 | 4.5 / 9 | +4.5 |
| Funding & adoption signal | 3 / 12 | 3 / 12 | 0 |
| Pricing transparency | 1.3 / 2.5 | 1.3 / 2.5 | 0 |
| Years in market | 0 / 6 | 6 / 6 | -6 |
Scroll horizontally to see every column.
Pricing
Epic Sepsis Model
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. Delivered within Epic licensing. |
SimpleSense
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Evidence
Epic Sepsis Model
FDA decisions
No FDA decision cited in our research as of November 2, 2026.
Peer-reviewed
5 PubMed records name Epic Sepsis Model.
- A Systematic Review and Meta-analysis of Externally Validated Epic Clinical Decision Support Tools. (opens in new tab)
- Evaluation of Sepsis Prediction Models before Onset of Treatment. (opens in new tab)
- Multicenter Prospective Validation of an Updated Proprietary Sepsis Prediction Model. (opens in new tab)
SimpleSense
FDA decisions
K232053 (opens in new tab)510(k)2023-12-08
SimpleSense-BP, SimpleSense-BP Software Application
K212160 (opens in new tab)510(k)2021-09-22
SimpleSENSE Platform
K201669 (opens in new tab)510(k)2020-11-06
SimpleSENSE
K161431 (opens in new tab)510(k)2016-11-30
SimplECG
Peer-reviewed
3 PubMed records name SimpleSense.
- Multiparametric cloth-based wearable, SimpleSense, estimates blood pressure. (opens in new tab)
- Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension. (opens in new tab)
- Nanotechnology and Artificial Intelligence: An Emerging Paradigm for Postoperative Patient Care. (opens in new tab)
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Epic Sepsis Model | SimpleSense |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | n/a | 2014 |
| HQ | US | US |
Scroll horizontally to see both columns.
Common questions
Open the full decision support comparison
Differential diagnosis, treatment guidance, drug interactions, evidence-grounded Q&A. The CDS landscape ranges from the UpToDate gold standard to physician-only OpenEvidence. We compared what clinicians actually use.