Gleamer vs Pearl
Gleamer reads medical radiographs. BoneView covers fractures, dislocations and bone lesions, and ChestView covers pneumothorax, consolidation, nodules and pleural effusion. The vendor says it runs at 3,500-plus clinical sites in 50-plus countries, and its home page names Affidea and Hirslanden. Hospital imaging departments read these films.
Pearl reads dental radiographs for dentists and DSOs. Second Opinion marks up to 18 findings on bitewing, periapical and panoramic images, including caries, calculus and bone loss. openFDA lists eight Second Opinion decisions, the latest K250525 for panoramic radiographs on November 14, 2025. A 2025 Diagnostics study of Second Opinion v1.1 reported 91.0% sensitivity and 87% specificity for caries. The product list on gleamer.ai names no dental tool, while Pearl's FAQ names DEXIS, Carestream, Open Dental and Eaglesoft among the practice software it connects to.
Radiology · Reviewed November 2, 2026
When to pick each one
Gleamer
- BoneView for fractures, ChestView for chest X-ray
- Vendor claims 3,500+ clinical sites in 50+ countries
- Home page names Affidea and Hirslanden
Pearl
- Up to 18 dental findings per radiograph
- Eight Second Opinion 510(k) decisions on openFDA
- FAQ names DEXIS, Carestream, Open Dental and Eaglesoft
Score
Each row shows points earned of points available under the published rubric.
Gleamer
56of 100
Pearl
33of 100
| Dimension | Gleamer | Pearl | Difference |
|---|---|---|---|
| FDA clearance | 18 / 18 | 18 / 18 | 0 |
| HIPAA / SOC2 / BAA | 0 / 10 | 0 / 10 | 0 |
| EHR integrations (count) | 0 / 4.2 | 0 / 4.2 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 2.4 | 0 / 2.4 | 0 |
| Peer-reviewed papers | 18.2 / 18.2 | 0 / 18.2 | +18.2 |
| RCT / meta-analysis / systematic review | 0 / 7.8 | 0 / 7.8 | 0 |
| Funding & adoption signal | 8.4 / 12 | 3 / 12 | +5.4 |
| Pricing transparency | 2.5 / 5 | 2.5 / 5 | 0 |
| Years in market | 0 / 6 | 4.2 / 6 | -4.2 |
Scroll horizontally to see every column.
Pricing
Gleamer
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. Demo request only. |
Pearl
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Evidence
Gleamer
FDA decisions
K252486 (opens in new tab)510(k)2026-09-09
ChestView US (1.1)
K241620 (opens in new tab)510(k)2025-02-27
ChestView US
K241593 (opens in new tab)510(k)2025-02-05
BoneMetrics (US)
K213253 (opens in new tab)510(k)2023-06-30
Pixyl.Neuro
K222176 (opens in new tab)510(k)2023-03-02
BoneView
Show 1 more
K212365 (opens in new tab)510(k)2022-03-01
BoneView
Peer-reviewed
5 PubMed records name Gleamer.
- Opinion paper: artificial intelligence as a clinical ally in lung cancer detection-the case for Gleamer's ChestView. (opens in new tab)
- AI model for automatic spinopelvic and spinal alignment parameters measurement from EOS. (opens in new tab)
- Fracture Detection on Bone Radiographs: The Impact of an AI Tool on Orthopaedic Night Shifts. (opens in new tab)
Pearl
FDA decisions
K250525 (opens in new tab)510(k)2025-11-14
Second Opinion Panoramic
K243234 (opens in new tab)510(k)2025-06-12
Second Opinion CS
K243989 (opens in new tab)510(k)2025-05-23
Second Opinion 3D
K243230 (opens in new tab)510(k)2025-05-09
Second Opinion BLE
K243893 (opens in new tab)510(k)2025-05-05
Second Opinion Pediatric
Show 3 more
K242600 (opens in new tab)510(k)2025-04-11
Second Opinion Periapical Radiolucency Contours
K242522 (opens in new tab)510(k)2025-01-16
Second Opinion CC
K210365 (opens in new tab)510(k)2022-03-04
Second Opinion
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Gleamer | Pearl |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | n/a | 2019 |
| HQ | FR | US |
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Common questions
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