Zio vs Isabel Healthcare

Zio and Isabel's DDx Companion answer different questions: one follows a patient's heart rhythm, the other turns signs and symptoms into a ranked differential.

Zio is a patch service. A deep neural network flags arrhythmias, cardiac technicians validate the findings and a physician report follows, and iRhythm bills payers through Medicare-enrolled IDTFs without a public price. The vendor says Isabel is in the Cerner App Gallery, gives Epic clients info-button access and has had an API since 2010. In a 2025 Orphanet Journal of Rare Diseases study of 100 rare-disease patients, Isabel's top ten matched at least one case-conference diagnosis in 28% of cases, and the authors say history filtering may limit standalone effectiveness. The vendor claims 96% accuracy for the correct disease in its top-ten differential. Zio is the wrong shape for an internist who needs a differential, and Isabel offers nothing to a cardiology practice that must detect arrhythmias.