Optellum Virtual Nodule Clinic vs Pearl
Optellum sells to pulmonologists and radiology departments running a lung nodule clinic. Its one 510(k), K202300 from March 2021, covers the Virtual Nodule Clinic including the LCP-CNN risk score on lung CT. The reimbursement page lists CPT Category III codes 0721T and +0722T and puts Medicare's 2026 hospital outpatient rate under APC 1508 at $650.50 (national average, before deductibles). The trust center lists ISO 13485:2016, ISO/IEC 27001 and NHS DSPT.
A general dentist reading bitewings is Pearl's customer. Its first Second Opinion clearance, K210365 from March 2022, marks suspected caries on bitewing and periapical radiographs of permanent teeth in patients 12 and over. A 2025 Diagnostics study of Second Opinion reported 91.0% sensitivity for caries and 86.6% for periapical lesions. A 2026 Caries Research comparison of five commercial systems put secondary caries sensitivity between 0.327 and 0.487 across all of them.
The two sell to different institutions. Optellum names hospital customers such as UConn Health, Penn Medicine and Vanderbilt University Medical Center, and Pearl's pages cite 100+ DSOs and a Smile Brands rollout.
Radiology · Reviewed November 2, 2026
Optellum Virtual Nodule Clinic
by Optellum · founded 2016
FDA-cleared AI that scores lung cancer risk for CT lung nodules and tracks them, for pulmonologists and radiology departments.
Pearl
by Pearl Inc. · founded 2019
FDA-cleared dental x-ray AI (Second Opinion) that marks caries, bone loss and restorations, for dentists and DSOs.
When to pick each one
Optellum Virtual Nodule Clinic
- Lung nodule risk score on CT, K202300 March 2021
- Trust center lists ISO 13485 and ISO 27001
Pearl
- Caries detection on bitewing and periapical films
- Three Second Opinion clearances, ages 4, 12 and 19 and over
Score
Each row shows points earned of points available under the published rubric.
Optellum Virtual Nodule Clinic
35of 100
Pearl
33of 100
| Dimension | Optellum Virtual Nodule Clinic | Pearl | Difference |
|---|---|---|---|
| FDA clearance | 18 / 18 | 18 / 18 | 0 |
| HIPAA / SOC2 / BAA | 0 / 10 | 0 / 10 | 0 |
| EHR integrations (count) | 0 / 4.2 | 0 / 4.2 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 2.4 | 0 / 2.4 | 0 |
| Peer-reviewed papers | 0 / 18.2 | 0 / 18.2 | 0 |
| RCT / meta-analysis / systematic review | 0 / 7.8 | 0 / 7.8 | 0 |
| Funding & adoption signal | 3 / 12 | 3 / 12 | 0 |
| Pricing transparency | 2.5 / 5 | 2.5 / 5 | 0 |
| Years in market | 6 / 6 | 4.2 / 6 | +1.8 |
Scroll horizontally to see every column.
Pricing
Optellum Virtual Nodule Clinic
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. Reimbursement fact, not a price: CPT Category III codes 0721T and +0722T; Medicare hospital outpatient APC 1508 rate $650.50 for 2026 (national average, before deductibles). |
Pearl
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Evidence
Optellum Virtual Nodule Clinic
FDA decisions
K202300 (opens in new tab)510(k)2021-03-05
Optellum Virtual Nodule Clinic, Optellum software, Optellum platform
Pearl
FDA decisions
K250525 (opens in new tab)510(k)2025-11-14
Second Opinion Panoramic
K243234 (opens in new tab)510(k)2025-06-12
Second Opinion CS
K243989 (opens in new tab)510(k)2025-05-23
Second Opinion 3D
K243230 (opens in new tab)510(k)2025-05-09
Second Opinion BLE
K243893 (opens in new tab)510(k)2025-05-05
Second Opinion Pediatric
Show 3 more
K242600 (opens in new tab)510(k)2025-04-11
Second Opinion Periapical Radiolucency Contours
K242522 (opens in new tab)510(k)2025-01-16
Second Opinion CC
K210365 (opens in new tab)510(k)2022-03-04
Second Opinion
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Optellum Virtual Nodule Clinic | Pearl |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | 2016 | 2019 |
| HQ | GB | US |
Scroll horizontally to see both columns.
Common questions
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