Pearl vs Tempus AI Imaging
Pearl's Second Opinion goes to a dentist's operatory. According to the vendor FAQ, it marks up to 18 findings per radiograph, including caries, periapical radiolucency, calculus and bone loss, and it connects to imaging and practice software such as DEXIS, Carestream, Open Dental and Eaglesoft. Tempus Pixel goes to a hospital radiology or oncology service, where it segments lesions on CT and MR, tracks them across studies and produces response reports.
Tempus's radiology page addresses radiologists and oncologists, and Pearl's pages address dental teams, so the two products read different images for different departments. The cardiac MR update lets Pixel generate T1 and T2 maps from raw MRI data, and the Tempus page claims 100+ health systems.
Tempus bought Arterys in October 2022, and the September 2025 Pixel clearance, K252539, still lists Arterys as applicant.
Radiology · Reviewed November 2, 2026
Pearl
by Pearl Inc. · founded 2019
FDA-cleared dental x-ray AI (Second Opinion) that marks caries, bone loss and restorations, for dentists and DSOs.
Tempus AI Imaging
by Tempus AI
Tempus Pixel (formerly Arterys): cloud imaging AI for radiology and oncology reads, with cardiac MR, lung, breast and prostate tools.
When to pick each one
Pearl
- Vendor FAQ, up to 18 findings per film
- Names DEXIS, Carestream, Open Dental, Eaglesoft
- Bitewing, periapical and panoramic films
Tempus AI Imaging
- Oncology lesion tracking on CT and MR
- Cardiac MR T1 and T2 maps from raw data
- Radiology and oncology reads in one cloud tool
Score
Each row shows points earned of points available under the published rubric.
Pearl
33of 100
Tempus AI Imaging
32of 100
| Dimension | Pearl | Tempus AI Imaging | Difference |
|---|---|---|---|
| FDA clearance | 18 / 18 | 18 / 18 | 0 |
| HIPAA / SOC2 / BAA | 0 / 10 | 0 / 10 | 0 |
| EHR integrations (count) | 0 / 4.2 | 0 / 4.2 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 2.4 | 0 / 2.4 | 0 |
| Peer-reviewed papers | 0 / 18.2 | 0 / 18.2 | 0 |
| RCT / meta-analysis / systematic review | 0 / 7.8 | 0 / 7.8 | 0 |
| Funding & adoption signal | 3 / 12 | 6 / 12 | -3 |
| Pricing transparency | 2.5 / 5 | 2.5 / 5 | 0 |
| Years in market | 4.2 / 6 | 0 / 6 | +4.2 |
Scroll horizontally to see every column.
Pricing
Pearl
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Tempus AI Imaging
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Evidence
Pearl
FDA decisions
K250525 (opens in new tab)510(k)2025-11-14
Second Opinion Panoramic
K243234 (opens in new tab)510(k)2025-06-12
Second Opinion CS
K243989 (opens in new tab)510(k)2025-05-23
Second Opinion 3D
K243230 (opens in new tab)510(k)2025-05-09
Second Opinion BLE
K243893 (opens in new tab)510(k)2025-05-05
Second Opinion Pediatric
Show 3 more
K242600 (opens in new tab)510(k)2025-04-11
Second Opinion Periapical Radiolucency Contours
K242522 (opens in new tab)510(k)2025-01-16
Second Opinion CC
K210365 (opens in new tab)510(k)2022-03-04
Second Opinion
Tempus AI Imaging
FDA decisions
K252539 (opens in new tab)510(k)2025-09-03
Tempus Pixel (applicant Arterys, Inc.)
K203744 (opens in new tab)510(k)2022-03-14
Arterys MICA (applicant Arterys, Inc.)
K192437 (opens in new tab)510(k)2020-03-25
Arterys MICA (applicant Arterys, Inc.)
K182034 (opens in new tab)510(k)2018-10-17
Arterys MICA (applicant Arterys, Inc.)
K173542 (opens in new tab)510(k)2018-01-25
Arterys Oncology DL (applicant Arterys, Inc.)
Show 3 more
K171544 (opens in new tab)510(k)2017-07-18
Arterys Viewer (applicant Arterys, Inc.)
K163253 (opens in new tab)510(k)2017-01-05
Arterys Cardio DL (applicant Arterys, Inc.)
K162513 (opens in new tab)510(k)2016-10-28
Arterys Software v2.0 (applicant Arterys, Inc.)
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Pearl | Tempus AI Imaging |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | 2019 | n/a |
| HQ | US | US |
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Common questions
Open the full radiology comparison
Acute-care triage, mammography screening, CCTA plaque analysis, mobile MRI. 30+ FDA-cleared platforms across stroke, oncology, cardiac. Enterprise sales only — we compared what's deployed where.