Avo vs SimpleSense
Nanowear's 303-subject prospective multicentre study of its cuffless blood pressure monitor (J Cardiovasc Transl Res 2025) came from vendor-affiliated authors, ran four weeks and was internal validation only, and the authors call for external validation. A 2022 Sci Rep paper on its multiparametric cloth-based SimpleSense estimating blood pressure carries the same Nanowear affiliation. The garment and its cloud analytics hold four FDA 510(k) clearances, the newest SimpleSense-BP in December 2023. The company is in Brooklyn and was founded in 2014, and listed funding is $1.52M over two rounds per Tracxn. A heart failure clinic or cardiology practice is the buyer, with no public price.
A medical director rolling out documentation and decision support looks to Avo, whose homepage figures are vendor claims with no study link: a 35% cut in note time per patient and $11.6M in annual savings at an ambulatory organization. One is remote cardiometabolic monitoring bought by a clinic, the other chart tooling bought by a health system.
Decision support · Reviewed November 2, 2026

Avo
by AvoMD
Guideline-based clinical decision support and EHR chart assistants for health systems, with ambient documentation.

SimpleSense
by Nanowear · founded 2014
Cloth wearable with 510(k) cleared AI cloud analytics for remote cardiac monitoring and cuffless blood pressure.
When to pick each one
Avo
- Vendor-claimed 35% less note time per patient
- Documentation and decision support in one platform
SimpleSense
- Four FDA 510(k) clearances, cuffless blood pressure
- Home heart failure monitoring with a cloth garment
- 303-subject study, internal validation only
Score
Each row shows points earned of points available under the published rubric.
Avo
18of 100
SimpleSense
49of 100
| Dimension | Avo | SimpleSense | Difference |
|---|---|---|---|
| FDA clearance | 0 / 12 | 12 / 12 | -12 |
| HIPAA / SOC2 / BAA | 6 / 10 | 0 / 10 | +6 |
| EHR integrations (count) | 1.7 / 5.6 | 0 / 5.6 | +1.7 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 3.4 / 4.8 | 0 / 4.8 | +3.4 |
| Bidirectional write-back | 0 / 1.2 | 0 / 1.2 | 0 |
| Peer-reviewed papers | 0 / 21 | 14.7 / 21 | -14.7 |
| RCT / meta-analysis / systematic review | 0 / 9 | 4.5 / 9 | -4.5 |
| Funding & adoption signal | 3 / 12 | 3 / 12 | 0 |
| Pricing transparency | 1.3 / 2.5 | 1.3 / 2.5 | 0 |
| Years in market | 0 / 6 | 6 / 6 | -6 |
Scroll horizontally to see every column.
Pricing
Avo
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. The pricing page returns 404; the site offers a demo booking only. |
SimpleSense
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Evidence
Avo
FDA decisions
No FDA decision cited in our research as of November 2, 2026.
SimpleSense
FDA decisions
K232053 (opens in new tab)510(k)2023-12-08
SimpleSense-BP, SimpleSense-BP Software Application
K212160 (opens in new tab)510(k)2021-09-22
SimpleSENSE Platform
K201669 (opens in new tab)510(k)2020-11-06
SimpleSENSE
K161431 (opens in new tab)510(k)2016-11-30
SimplECG
Peer-reviewed
3 PubMed records name SimpleSense.
- Multiparametric cloth-based wearable, SimpleSense, estimates blood pressure. (opens in new tab)
- Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension. (opens in new tab)
- Nanotechnology and Artificial Intelligence: An Emerging Paradigm for Postoperative Patient Care. (opens in new tab)
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Avo | SimpleSense |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Epic, athenahealth, MEDITECH | Not specified |
| Founded | n/a | 2014 |
| HQ | US | US |
Scroll horizontally to see both columns.
Common questions
Open the full decision support comparison
Differential diagnosis, treatment guidance, drug interactions, evidence-grounded Q&A. The CDS landscape ranges from the UpToDate gold standard to physician-only OpenEvidence. We compared what clinicians actually use.
