Bayesian Health vs Sepsis ImmunoScore

Prenosis scores adults who already have suspected sepsis in the ED or hospital, with a blood culture ordered. It takes up to 22 EHR parameters and returns one of four risk bands for the next 24 hours. The vendor says it has not been validated for ICU or Labor and Delivery units. Its published support includes a vendor-run 2024 NEJM AI development and validation study and two 2026 papers the vendor lists, in Diagnostics and JAMIA Open.

Bayesian Health says it watches every patient continuously and raises a high-risk flag in the chart, a design that descends from the Johns Hopkins TREWS system. A hospital sepsis program that wants every admitted adult watched from arrival should skip Prenosis, which scores only after sepsis is suspected. An ED medical director who wants a triage score at the point of suspicion fits Prenosis.

On payment, Prenosis's page says sepsis sits inside the DRG with no separate payment and points to a new ICD-10-PCS code for AI sepsis diagnostic tools from October 1, 2025. Medicare's add-on payment for Bayesian pays the hospital up to $61.84 per eligible fee-for-service inpatient case from October 1, 2026.