C8 Health vs Sepsis ImmunoScore
An ED or inpatient service that wants a risk score for adults with suspected sepsis is the Prenosis buyer. Sepsis ImmunoScore uses up to 22 EHR parameters and returns four risk bands, and Prenosis holds a De Novo grant, DEN230036, decided April 2, 2024. The vendor says it has not been validated for ICU or Labor and Delivery units, and the Sepsis ImmunoScore page names no EHR vendor. Its NEJM AI validation paper is vendor-run.
C8 Health is a protocol platform, founded at Geneva University Hospital in 2019, for hospital leaders reducing clinical variation. The vendor says its assistant, Panda AI, searches only vetted knowledge. openFDA lists no 510(k) under C8 Health, and the vendor makes no FDA claim. Sepsis risk scoring in the ED or inpatient units and protocol delivery across surgical units are different jobs for different buyers.
Decision support · Reviewed November 2, 2026
C8 Health
by C8 Health Inc. · founded 2019
Protocol knowledge platform for hospitals, with an AI assistant that answers only from the hospital's vetted content.
Sepsis ImmunoScore
by Prenosis
AI sepsis risk score from up to 22 EHR parameters for adults with suspected sepsis in the ED or hospital, FDA De Novo authorized.
When to pick each one
C8 Health
- Protocol governance and variation reduction across a hospital
- Founded at Geneva University Hospital in 2019
Sepsis ImmunoScore
- FDA De Novo, DEN230036, for sepsis prediction
- Risk score from up to 22 EHR parameters
- Adults with suspected sepsis in ED or hospital
Score
Each row shows points earned of points available under the published rubric.
C8 Health
32of 100
Sepsis ImmunoScore
37of 100
| Dimension | C8 Health | Sepsis ImmunoScore | Difference |
|---|---|---|---|
| FDA clearance | 0 / 12 | 12 / 12 | -12 |
| HIPAA / SOC2 / BAA | 10 / 10 | 0 / 10 | +10 |
| EHR integrations (count) | 0 / 5.6 | 0 / 5.6 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 4.8 | 0 / 4.8 | 0 |
| Bidirectional write-back | 0 / 1.2 | 0 / 1.2 | 0 |
| Peer-reviewed papers | 8.4 / 21 | 14.7 / 21 | -6.3 |
| RCT / meta-analysis / systematic review | 0 / 9 | 0 / 9 | 0 |
| Funding & adoption signal | 3 / 12 | 3 / 12 | 0 |
| Pricing transparency | 1.3 / 2.5 | 1.3 / 2.5 | 0 |
| Years in market | 4.2 / 6 | 0 / 6 | +4.2 |
Scroll horizontally to see every column.
Pricing
C8 Health
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Sepsis ImmunoScore
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. Demo or contact only. |
Evidence
C8 Health
FDA decisions
No FDA decision cited in our research as of November 2, 2026.
Peer-reviewed
1 PubMed record names C8 Health.
Sepsis ImmunoScore
FDA decisions
DEN230036 (opens in new tab)De Novo2024-04-02
Sepsis ImmunoScore
Peer-reviewed
2 PubMed records name Sepsis ImmunoScore.
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | C8 Health | Sepsis ImmunoScore |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | 2019 | n/a |
| HQ | US | US |
Scroll horizontally to see both columns.
Common questions
Open the full decision support comparison
Differential diagnosis, treatment guidance, drug interactions, evidence-grounded Q&A. The CDS landscape ranges from the UpToDate gold standard to physician-only OpenEvidence. We compared what clinicians actually use.