Epic Sepsis Model vs Glass Health
Epic's sepsis model rates adult inpatients and ED patients every 15 minutes inside the EHR, with alert thresholds each hospital sets, and Epic shows no separate price for it. A hospital's informatics team configures it. Glass Health is bought by the clinician or clinic using it, with Lite at $0 per month and ad-sponsored, Starter at $20, Pro at $90 ad-free and Max at $200, all in USD. Only Max includes assisted EHR workflows for Epic, eClinicalWorks, athenahealth and Elation.
Glass says it provides a cited differential, must-not-miss flags and an ambient scribe, drawing on a knowledge base of 38M+ citations. A 2024 comparison by Finelli in The Neurologist ran four NEJM cases. Glass's AI got 1 of 4 right, ChatGPT-4 got 0 of 4 and a diagnostic generator got 4 of 4, in a small, non-randomized comparison. The company is Y Combinator W23 with a $5M seed round led by Initialized Capital.
Epic's score has outside validations: an AUROC of 0.63 in Michigan Medicine's 2021 study, and a positive predictive value of 0.13 to 0.26 for the updated version in a 2026 four-system study.
Decision support · Reviewed November 2, 2026
Epic Sepsis Model
by Epic Systems
Sepsis risk score calculated every 15 minutes inside the Epic EHR, with alert thresholds set by each hospital.
Glass Health
by Glass Health · founded 2021
DDx plus literature-grounded A&P plus ambient scribe in one workflow.
When to pick each one
Epic Sepsis Model
- Scores adult inpatients and ED patients every 15 minutes
- Alert thresholds set by each hospital
- Updated version AUROC 0.82 to 0.92 in 2026 study
Glass Health
- Lite $0, Starter $20, Pro $90, Max $200 monthly
- EHR workflows only on the Max tier
- Vendor says cited differentials plus ambient scribe
Score
Each row shows points earned of points available under the published rubric.
Epic Sepsis Model
41of 100
Glass Health
42of 100
| Dimension | Epic Sepsis Model | Glass Health | Difference |
|---|---|---|---|
| FDA clearance | 0 / 12 | 0 / 12 | 0 |
| HIPAA / SOC2 / BAA | 0 / 10 | 6 / 10 | -6 |
| EHR integrations (count) | 0 / 5.6 | 2.8 / 5.6 | -2.8 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 4.8 | 3.4 / 4.8 | -3.4 |
| Bidirectional write-back | 0 / 1.2 | 0 / 1.2 | 0 |
| Peer-reviewed papers | 21 / 21 | 8.4 / 21 | +12.6 |
| RCT / meta-analysis / systematic review | 9 / 9 | 0 / 9 | +9 |
| Funding & adoption signal | 3 / 12 | 8.4 / 12 | -5.4 |
| Pricing transparency | 1.3 / 2.5 | 2.5 / 2.5 | -1.2 |
| Years in market | 0 / 6 | 4.2 / 6 | -4.2 |
Scroll horizontally to see every column.
Pricing
Epic Sepsis Model
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. Delivered within Epic licensing. |
Glass Health
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Lite | n/a | n/a | Limited scribing and clinical decision support. Carries ad sponsorships. |
| Starter | $20 | n/a | Carries ad sponsorships. |
| Pro | $90 | n/a | Most popular tier, ad-free. |
| Max | $200 | n/a | For clinics. EHR integration (Athena, Epic, eCW, Elation) is available only on this tier. |
Evidence
Epic Sepsis Model
FDA decisions
No FDA decision cited in our research as of November 2, 2026.
Peer-reviewed
5 PubMed records name Epic Sepsis Model.
- A Systematic Review and Meta-analysis of Externally Validated Epic Clinical Decision Support Tools. (opens in new tab)
- Evaluation of Sepsis Prediction Models before Onset of Treatment. (opens in new tab)
- Multicenter Prospective Validation of an Updated Proprietary Sepsis Prediction Model. (opens in new tab)
Glass Health
FDA decisions
No FDA decision cited in our research as of October 26, 2026.
Peer-reviewed
1 PubMed record names Glass Health.
Community
1 post sourced: 0 positive, 1 neutral, 0 negative.
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Epic Sepsis Model | Glass Health |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Epic, athenahealth, eClinicalWorks, Elation |
| Founded | n/a | 2021 |
| HQ | US | US |
Scroll horizontally to see both columns.
Common questions
Open the full decision support comparison
Differential diagnosis, treatment guidance, drug interactions, evidence-grounded Q&A. The CDS landscape ranges from the UpToDate gold standard to physician-only OpenEvidence. We compared what clinicians actually use.