Epic Sepsis Model vs Sepsis ImmunoScore

Prenosis's Sepsis ImmunoScore holds FDA De Novo DEN230036, decided April 2, 2024. It scores adults admitted to the ED or hospital with suspected sepsis from up to 22 EHR parameters in four risk bands, and the vendor says it has not been validated in ICU or labor and delivery units. Its NEJM AI development and validation paper is vendor-run, no EHR is named on the product page, and no price is public.

Both tools address inpatient and ED sepsis, so a hospital choosing sepsis software can weigh them. The Epic Sepsis Model has no record on openFDA and runs only inside Epic. The 2021 Michigan Medicine study of the first version measured an AUROC of 0.63 with 67 percent of sepsis cases missed, and the 2026 prospective study of version 2 across four US systems found AUROC of 0.82 to 0.92 but PPV of 0.13 to 0.26 and a high alert burden. For a hospital that must buy FDA-authorized sepsis software, the Epic Sepsis Model loses. A hospital already on Epic that is willing to tune its own thresholds can run it within the EHR it licenses.