Glass Health vs Zio
A 2024 report in The Neurologist scored GLASS AI at 1 of 4, ChatGPT-4 at 0 of 4 and the diagnostic generator at 4 of 4 on four NEJM cases, a small non-randomized comparison of a differential tool on case vignettes. iRhythm points to a 2019 Nature Medicine paper on a deep neural network for ambulatory ECG arrhythmias as the basis of its algorithm, a 2019 systematic review covers arrhythmia detection with the Zio patch, and the 99% physician-agreement figure on end-of-wear reports is iRhythm's own claim.
Glass sells to the clinician by subscription, $0 to $200 per month, with ads on Lite and Starter and Pro at $90 ad-free. Its buyer wants note drafting, billing and coding suggestions and a cited differential. Zio has no public price and is billed to payers through Medicare-enrolled IDTFs. One product documents the visit and the other records rhythm at home, and the physician who wants an arrhythmia work-up on a patient at home is the Zio customer.
Decision support · Reviewed November 2, 2026
Glass Health
by Glass Health · founded 2021
DDx plus literature-grounded A&P plus ambient scribe in one workflow.
Zio
by iRhythm Technologies · founded 2006
Zio ECG patch service: a deep-learning algorithm flags arrhythmias, cardiac technicians validate them, and a physician report follows.
When to pick each one
Glass Health
- Pro is $90 per month and ad-free
- Note drafting with billing and coding suggestions
- BAAs offered, vendor-stated
Zio
- Ambulatory ECG patch monitoring service
- Billed to payers through IDTFs, no clinic price
Score
Each row shows points earned of points available under the published rubric.
Glass Health
42of 100
Zio
69of 100
| Dimension | Glass Health | Zio | Difference |
|---|---|---|---|
| FDA clearance | 0 / 12 | 12 / 12 | -12 |
| HIPAA / SOC2 / BAA | 6 / 10 | 0 / 10 | +6 |
| EHR integrations (count) | 2.8 / 5.6 | 0 / 5.6 | +2.8 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 3.4 / 4.8 | 0 / 4.8 | +3.4 |
| Bidirectional write-back | 0 / 1.2 | 0 / 1.2 | 0 |
| Peer-reviewed papers | 8.4 / 21 | 21 / 21 | -12.6 |
| RCT / meta-analysis / systematic review | 0 / 9 | 9 / 9 | -9 |
| Funding & adoption signal | 8.4 / 12 | 8.4 / 12 | 0 |
| Pricing transparency | 2.5 / 2.5 | 1.3 / 2.5 | +1.3 |
| Years in market | 4.2 / 6 | 6 / 6 | -1.8 |
Scroll horizontally to see every column.
Pricing
Glass Health
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Lite | n/a | n/a | Limited scribing and clinical decision support. Carries ad sponsorships. |
| Starter | $20 | n/a | Carries ad sponsorships. |
| Pro | $90 | n/a | Most popular tier, ad-free. |
| Max | $200 | n/a | For clinics. EHR integration (Athena, Epic, eCW, Elation) is available only on this tier. |
Zio
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. |
Evidence
Glass Health
FDA decisions
No FDA decision cited in our research as of October 26, 2026.
Peer-reviewed
1 PubMed record names Glass Health.
Community
1 post sourced: 0 positive, 1 neutral, 0 negative.
Zio
FDA decisions
K252859 (opens in new tab)510(k)2026-05-29
ZEUS Platform (FG0501US, DQK)
K243650 (opens in new tab)510(k)2025-08-15
Zio monitor (DFG0001)
K240177 (opens in new tab)510(k)2024-10-30
Zio AT device (A100A1001, DSI)
K240029 (opens in new tab)510(k)2024-10-21
Zio AT device (A100A1001, QYX)
K222389 (opens in new tab)510(k)2023-02-15
ZEUS System
Show 13 more
K213409 (opens in new tab)510(k)2022-07-19
ZEUS System (Zio Watch)
K202359 (opens in new tab)510(k)2021-05-21
Zio Monitor
K202527 (opens in new tab)510(k)2021-05-21
ZEUS System
K190593 (opens in new tab)510(k)2019-08-23
Zio XT ECG Monitoring System, Zio AT
K181502 (opens in new tab)510(k)2018-08-29
Zio AT ECG Monitoring System, ZEUS System
K163512 (opens in new tab)510(k)2017-06-02
Zio AT ECG Monitoring System
K143513 (opens in new tab)510(k)2015-06-19
ZIO SR ECG Monitoring Service
K142681 (opens in new tab)510(k)2014-11-21
ZEUS System
K121319 (opens in new tab)510(k)2012-07-18
ZIO PATCH
K113862 (opens in new tab)510(k)2012-02-06
ZIO PATCH
K091075 (opens in new tab)510(k)2009-07-21
ZEUS (ZIO ECG UTILIZATION SERVICE) SYSTEM
K090363 (opens in new tab)510(k)2009-05-08
ZIO PATCH Z100
K081471 (opens in new tab)510(k)2008-06-24
ECARD AND CCARD
Peer-reviewed
5 PubMed records name Zio.
- Physical activity cut-points for older adults using the Zio XT onboard accelerometer. (opens in new tab)
- Validation of a Zio XT Patch Accelerometer for the Objective Assessment of Physical Activity in the Atherosclerosis Risk in Communities (ARIC) Study. (opens in new tab)
- Zio® XT Patches in Pediatrics During the COVID-19 Pandemic: Comparisons Between In-Person and Mail-Home Application. (opens in new tab)
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Glass Health | Zio |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Epic, athenahealth, eClinicalWorks, Elation | Not specified |
| Founded | 2021 | 2006 |
| HQ | US | US |
Scroll horizontally to see both columns.
Common questions
Open the full decision support comparison
Differential diagnosis, treatment guidance, drug interactions, evidence-grounded Q&A. The CDS landscape ranges from the UpToDate gold standard to physician-only OpenEvidence. We compared what clinicians actually use.