Isabel Healthcare vs Sepsis ImmunoScore
Prenosis's vendor page limits Sepsis ImmunoScore to adults 18 and over admitted through the ED or hospital with suspected sepsis and a blood culture ordered, and says it does not replace clinical judgment. The vendor ran the 2024 NEJM AI development and validation study, and lists a 2026 Diagnostics paper comparing the score with clinical scores and biomarkers. An ED medical director weighing a sepsis program is the audience, and the vendor sells by demo or contact.
Isabel is a differential generator sold to individual clinicians. The vendor says DDx Companion covers more than 10,000 conditions and answers in under 90 seconds, and Standard costs $149 per year. Isabel Healthcare Ltd is a UK company co-founded in 1999. A separate Self-Triage product asks 11 standard questions.
A ranked differential and a sepsis risk band answer different questions. An individual clinician subscribing at $149 per year and an ED director with a sepsis program buy separately.
Decision support · Reviewed November 2, 2026
Isabel Healthcare
by Isabel Healthcare · founded 1999
Differential-diagnosis generator with self-triage and educator products. The vendor says it is used in over 90 countries and 14 languages.
Sepsis ImmunoScore
by Prenosis
AI sepsis risk score from up to 22 EHR parameters for adults with suspected sepsis in the ED or hospital, FDA De Novo authorized.
When to pick each one
Isabel Healthcare
- Vendor: 10,000+ conditions in the differential
- Standard $149 per year, student rate $49
Sepsis ImmunoScore
- FDA De Novo authorization for sepsis risk scoring
- Scores adults when a blood culture is ordered
Score
Each row shows points earned of points available under the published rubric.
Isabel Healthcare
35of 100
Sepsis ImmunoScore
37of 100
| Dimension | Isabel Healthcare | Sepsis ImmunoScore | Difference |
|---|---|---|---|
| FDA clearance | 0 / 12 | 12 / 12 | -12 |
| HIPAA / SOC2 / BAA | 0 / 10 | 0 / 10 | 0 |
| EHR integrations (count) | 0 / 5.6 | 0 / 5.6 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 4.8 | 0 / 4.8 | 0 |
| Bidirectional write-back | 0 / 1.2 | 0 / 1.2 | 0 |
| Peer-reviewed papers | 14.7 / 21 | 14.7 / 21 | 0 |
| RCT / meta-analysis / systematic review | 0 / 9 | 0 / 9 | 0 |
| Funding & adoption signal | 6 / 12 | 3 / 12 | +3 |
| Pricing transparency | 2.5 / 2.5 | 1.3 / 2.5 | +1.3 |
| Years in market | 6 / 6 | 0 / 6 | +6 |
Scroll horizontally to see every column.
Pricing
Isabel Healthcare
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Standard | n/a | $149 | EUR 139 incl. VAT. 30-day free trial. |
| Premium | n/a | $199 | EUR 179 incl. VAT. Adds an LLM layer (English only). |
| Student / resident | n/a | $49 | Not available to EU students. 50% discount for listed emerging economies. |
| Institutional | n/a | n/a | Demo request, no public price. The API has been available since 2010. |
Sepsis ImmunoScore
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | n/a | n/a | No public price. Demo or contact only. |
Evidence
Isabel Healthcare
FDA decisions
No FDA decision cited in our research as of October 20, 2026.
Peer-reviewed
2 PubMed records name Isabel Healthcare.
- Cracking the code: a head-to-head comparison of expert clinicians and artificial intelligence in diagnosing rare diseases. (opens in new tab)
- Is language an issue? Accuracy of the German computerized diagnostic decision support system ISABEL and cross-validation with the English counterpart. (opens in new tab)
Sepsis ImmunoScore
FDA decisions
DEN230036 (opens in new tab)De Novo2024-04-02
Sepsis ImmunoScore
Peer-reviewed
2 PubMed records name Sepsis ImmunoScore.
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Isabel Healthcare | Sepsis ImmunoScore |
|---|---|---|
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | 1999 | n/a |
| HQ | UK | US |
Scroll horizontally to see both columns.
Common questions
Open the full decision support comparison
Differential diagnosis, treatment guidance, drug interactions, evidence-grounded Q&A. The CDS landscape ranges from the UpToDate gold standard to physician-only OpenEvidence. We compared what clinicians actually use.