Etiometry Platform vs Sepsis ImmunoScore

Etiometry's four indices cover oxygen delivery, CO2 ventilation, lactate and pH in post-surgical or ventilated patients, mostly children, which leaves an ED sepsis lead outside its indications. Prenosis was built for that lead's patient. Its Sepsis ImmunoScore holds De Novo DEN230036 from April 2024 and reads up to 22 EHR parameters, including procalcitonin, CRP and lactate, then returns one of four risk bands for deterioration within 24 hours in adults admitted to the ED or hospital with suspected sepsis. Its NEJM AI paper is a development and validation study run by the company. Per its product page, sepsis is paid through the DRG with no separate payment for the tool, and a new ICD-10-PCS code for AI sepsis tools applies from October 2025.

Prenosis states that the score has not been validated in ICU or Labor and Delivery units. An ICU director shopping for risk analytics can rule it out on that wording and look at Etiometry's adult oxygen-delivery index.