MedAI Verdict
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Micromedex vs UpToDate Lexidrug

Published comparisons put Micromedex and Lexicomp at the top for interaction accuracy, so a pharmacy already running Micromedex has little reason to switch on accuracy alone. Two results favor Lexicomp. In a Janusmed comparison of 109 alerts rated C or D, 82% got a similar alert in Lexicomp and 69% in Micromedex, and Yale New Haven swapped Micromedex for Lexicomp in September 2022. A renal transplant study found 8.2% of Micromedex-flagged interactions clinically relevant against 4.2% for Lexicomp, which favors Micromedex on alert noise. Micromedex names Poisindex, NeoFax and RED BOOK pricing, adds an AI search with cited answers, and is quoted per organization with no public price. Lexidrug suits the hospital pharmacist who wants Trissel's IV compatibility and the offline app on a personal subscription, listed at $29.99 per month in app stores. A pharmacy that wants RED BOOK pricing inside its drug reference should buy Micromedex, and Lexidrug loses that buyer.

Drug info · Reviewed November 1, 2026

Micromedex logo

Micromedex

by Merative

Drug reference with interaction checking, IV compatibility, toxicology and RED BOOK pricing, plus AI-powered search since September 2025.

UpToDate Lexidrug logo

UpToDate Lexidrug

by Wolters Kluwer

Drug reference with interaction analysis, dosing guidance and IV compatibility, from UpToDate (formerly Lexicomp).

When to pick each one

Micromedex

  • Poisindex and NeoFax content by name
  • RED BOOK pricing plus AI search with cited answers
  • Institutional subscription, quoted per organization
Read the full Micromedex review

UpToDate Lexidrug

  • Personal subscription, $29.99 per month in store listings
  • Trissel's IV compatibility and an offline app
  • Dosing for renal, hepatic and pregnancy considerations
Read the full UpToDate Lexidrug review

Score

Each row shows points earned of points available under the published rubric.

Micromedex

52of 100

Solid choice

UpToDate Lexidrug

30of 100

Competitive
Score by dimension for Micromedex and UpToDate Lexidrug
DimensionMicromedexUpToDate LexidrugDifference
EHR integrations (count)0 / 4.20 / 4.20
Top-3 EHR coverage (Epic / Oracle / Athena)0 / 2.40 / 2.40
Peer-reviewed papers14.7 / 210 / 21+14.7
RCT / meta-analysis / systematic review3 / 60 / 6+3
Funding & adoption signal10.9 / 15.615.6 / 15.6-4.7
Pricing transparency3 / 63 / 60
Years in market0 / 60 / 60

Scroll horizontally to see every column.

How scores are computed

Pricing

Micromedex

TierMonthlyAnnualNotes
Institutional subscriptionn/an/aNo public price, quoted per organization. No current individual subscription was found.

UpToDate Lexidrug

TierMonthlyAnnualNotes
Enterprisen/an/aNo public price, contact form only. Personal subscriptions are also sold (mobile app and store.uptodate.com), but the current personal price is not confirmed.

Compliance and integrations

Documented from each vendor’s own pages.

SpecMicromedexUpToDate Lexidrug
Free tierNo / unverifiedNo / unverified
HIPAANo / unverifiedNo / unverified
SOC 2 Type IINo / unverifiedNo / unverified
EHR integrationsNot specifiedNot specified
Foundedn/an/a
HQn/aNL

Scroll horizontally to see both columns.

Common questions

Open the full drug info comparison

Drug references (Lexidrug, Micromedex, Epocrates) and interaction checkers (Drugs.com, Medscape). Built for the clinician at the point of care.