Epocrates vs UpToDate Lexidrug
Epocrates and UpToDate Lexidrug both compete in drug info, but answer different questions. Epocrates is our pick for clinician drug app: Most-used clinician drug-reference app in the US, free tier. UpToDate Lexidrug earns the drug reference slot: Most-deployed drug reference in US health systems. Formerly Lexicomp. The right choice depends on whether your priority is clinician drug app or drug reference.
- Drug info
- 02
- May 23, 2026
Epocrates
by Epocrates (athenahealth/Bain) · founded 1998
Most-used clinician drug-reference app in the US.
- Free + $16.99/mo Plus + $159/yr Essentials.
- —
UpToDate Lexidrug
by Wolters Kluwer
Gold-standard drug reference + interaction screening (formerly Lexicomp).
- Enterprise (institutional only).
- —
How Epocrates and UpToDate Lexidrug compare
Pricing, compliance, and integrations sourced from vendor documentation. Verified May 23, 2026.
| Spec | Epocrates | UpToDate Lexidrug |
|---|---|---|
| Pricing | Free + $16.99/mo Plus + $159/yr Essentials. | Enterprise (institutional only). |
| Free tier | Yes | Yes |
| HIPAA | No / unverified | No / unverified |
| SOC 2 Type II | No / unverified | No / unverified |
| EHR integrations | Not specified | Not specified |
| Founded | 1998 | — |
| HQ | US | NL |
| Best for | Best free clinician drug app | Best institutional drug reference |
Scroll horizontally to see both columns.
When to pick each one
Best free clinician drug app
Most-used clinician drug-reference app in the US, free tier.
- Free + $16.99/mo Plus + $159/yr Essentials
- Pill ID, formulary, interactions
Best institutional drug reference
Most-deployed drug reference in US health systems. Formerly Lexicomp.
- Wolters Kluwer
- Drug-drug, drug-allergy, IV-compatibility screening
- Institutional standard
Open the full drug info comparison
Drug references (Lexidrug, Micromedex, Epocrates), interaction checkers, and emerging AI drug-discovery platforms (Insilico, Schrödinger, Recursion). Two distinct markets covered.
/best-ai-drug-information