Epocrates vs UpToDate Lexidrug
Epocrates and UpToDate Lexidrug both compete in drug info, but answer different questions. Epocrates is our pick for clinician drug app: Most-used clinician drug-reference app in the US, free tier. UpToDate Lexidrug earns the drug reference slot: Most-deployed drug reference in US health systems. Formerly Lexicomp. The right choice depends on whether your priority is clinician drug app or drug reference.
- Drug info
- 02
- October 20, 2026
Epocrates
by Epocrates (athenahealth) · founded 1998
Drug reference app with interaction checks, calculators, disease guidance and a beta AI Assist.
- USD 24.99/mo from
- —
UpToDate Lexidrug
by Wolters Kluwer
Drug reference with interaction analysis, dosing guidance and IV compatibility, from UpToDate (formerly Lexicomp).
- No public price, contact form only. Personal subscriptions are also sold (mobile app and store.uptodate.com), but the current personal price is not confirmed.
- —
How Epocrates and UpToDate Lexidrug compare
Pricing, compliance, and integrations sourced from vendor documentation. Verified October 20, 2026.
| Spec | Epocrates | UpToDate Lexidrug |
|---|---|---|
| Pricing | USD 24.99/mo from | No public price, contact form only. Personal subscriptions are also sold (mobile app and store.uptodate.com), but the current personal price is not confirmed. |
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | 1998 | — |
| HQ | US | NL |
| Best for | Best free clinician drug app | Best institutional drug reference |
Scroll horizontally to see both columns.
When to pick each one
Best free clinician drug app
Most-used clinician drug-reference app in the US, free tier.
- Free + $16.99/mo Plus + $159/yr Essentials
- Pill ID, formulary, interactions
Best institutional drug reference
Most-deployed drug reference in US health systems. Formerly Lexicomp.
- Wolters Kluwer
- Drug-drug, drug-allergy, IV-compatibility screening
- Institutional standard
Other head-to-heads worth reading
Open the full drug info comparison
Drug references (Lexidrug, Micromedex, Epocrates) and interaction checkers (Drugs.com, Medscape). Built for the clinician at the point of care.