Drugs.com Professional vs UpToDate Lexidrug
Drugs.com Professional and UpToDate Lexidrug both compete in drug info, but answer different questions. Drugs.com Professional is our pick for public + Pro: Strong free public tier + Pro $285/yr. UpToDate Lexidrug earns the drug reference slot: Most-deployed drug reference in US health systems. Formerly Lexicomp. The right choice depends on whether your priority is public + pro or drug reference.
- Drug info
- 02
- October 20, 2026
Drugs.com Professional
by Drugsite Trust
Free drug reference for professionals: AHFS monographs, interaction checker, pill identifier, FDA alerts and shortages. No AI features described.
- Free to use with a free sign-up to save drug and interaction lists. Funded by advertising. No Pro subscription or price was found.
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UpToDate Lexidrug
by Wolters Kluwer
Drug reference with interaction analysis, dosing guidance and IV compatibility, from UpToDate (formerly Lexicomp).
- No public price, contact form only. Personal subscriptions are also sold (mobile app and store.uptodate.com), but the current personal price is not confirmed.
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How Drugs.com Professional and UpToDate Lexidrug compare
Pricing, compliance, and integrations sourced from vendor documentation. Verified October 20, 2026.
| Spec | Drugs.com Professional | UpToDate Lexidrug |
|---|---|---|
| Pricing | Free to use with a free sign-up to save drug and interaction lists. Funded by advertising. No Pro subscription or price was found. | No public price, contact form only. Personal subscriptions are also sold (mobile app and store.uptodate.com), but the current personal price is not confirmed. |
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | — | — |
| HQ | NZ | NL |
| Best for | Best free public + Pro | Best institutional drug reference |
Scroll horizontally to see both columns.
When to pick each one
Best free public + Pro
Strong free public tier + Pro $285/yr.
- Drug database + interactions + IV compatibility + pill ID
Best institutional drug reference
Most-deployed drug reference in US health systems. Formerly Lexicomp.
- Wolters Kluwer
- Drug-drug, drug-allergy, IV-compatibility screening
- Institutional standard
Other head-to-heads worth reading
Open the full drug info comparison
Drug references (Lexidrug, Micromedex, Epocrates) and interaction checkers (Drugs.com, Medscape). Built for the clinician at the point of care.