Drugs.com Professional vs Epocrates
Drugs.com Professional and Epocrates both compete in drug info, but answer different questions. Drugs.com Professional is our pick for public + Pro: Strong free public tier + Pro $285/yr. Epocrates earns the clinician drug app slot: Most-used clinician drug-reference app in the US, free tier. The right choice depends on whether your priority is public + pro or clinician drug app.
- Drug info
- 02
- October 20, 2026
Drugs.com Professional
by Drugsite Trust
Free drug reference for professionals: AHFS monographs, interaction checker, pill identifier, FDA alerts and shortages. No AI features described.
- Free to use with a free sign-up to save drug and interaction lists. Funded by advertising. No Pro subscription or price was found.
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Epocrates
by Epocrates (athenahealth) · founded 1998
Drug reference app with interaction checks, calculators, disease guidance and a beta AI Assist.
- USD 24.99/mo from
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How Drugs.com Professional and Epocrates compare
Pricing, compliance, and integrations sourced from vendor documentation. Verified October 20, 2026.
| Spec | Drugs.com Professional | Epocrates |
|---|---|---|
| Pricing | Free to use with a free sign-up to save drug and interaction lists. Funded by advertising. No Pro subscription or price was found. | USD 24.99/mo from |
| Free tier | ||
| HIPAA | ||
| SOC 2 Type II | ||
| EHR integrations | Not specified | Not specified |
| Founded | — | 1998 |
| HQ | NZ | US |
| Best for | Best free public + Pro | Best free clinician drug app |
Scroll horizontally to see both columns.
When to pick each one
Best free public + Pro
Strong free public tier + Pro $285/yr.
- Drug database + interactions + IV compatibility + pill ID
Best free clinician drug app
Most-used clinician drug-reference app in the US, free tier.
- Free + $16.99/mo Plus + $159/yr Essentials
- Pill ID, formulary, interactions
Other head-to-heads worth reading
Open the full drug info comparison
Drug references (Lexidrug, Micromedex, Epocrates) and interaction checkers (Drugs.com, Medscape). Built for the clinician at the point of care.