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Editorial illustration: a pill bottle next to an open pharmacopeia page, with interaction warnings flagged in blue.

Medscape Drug Interaction Checker vs UpToDate Lexidrug

All comparisons

Scores are legacy evidence and documentation scores, not product-performance ratings. How it is computed

The cyclosporine and lercanidipine case shows the gap. In a renal transplant study Medscape rated the pair as no interaction, while Lexicomp and Micromedex rated it severe. A pharmacist screening transplant or oncology regimens is the Lexidrug buyer, since a herb and oncology drug screening study rated Lexicomp best, and the product adds Trissel's IV compatibility, toxicology and pharmacogenomic content and an offline mobile app. Enterprise pricing goes through a contact form, and app-store listings show a personal subscription at $29.99 per month. Medscape is free per third-party comparisons, covers drugs, OTC products, herbal supplements and common foods in five severity tiers, and names the mechanism. That study still called it the best free tool, and a 2016 comparison counted 202 of 400 interactions for it, on older versions, behind Lexicomp and Micromedex. Lexidrug is the poorer value for a pharmacy student or resident, who gets a first screen at no charge from Medscape.

Drug info · Reviewed November 1, 2026

On this page

Drug interaction lookup for prescription drugs, OTC medications, herbal supplements and some foods, with severity categories.

UpToDate Lexidrug logo

UpToDate Lexidrug

by Wolters Kluwer

Drug reference with interaction analysis, dosing guidance and IV compatibility, from UpToDate (formerly Lexicomp).

When to pick each one

Medscape Drug Interaction Checker

  • Free to use per third-party comparisons
  • Mechanism shown for each interaction
  • Five severity tiers, Contraindicated to Minor
Read the full Medscape Drug Interaction Checker review

UpToDate Lexidrug

  • Trissel's IV compatibility and renal dosing guidance
  • Lexicomp rated best in a herb and oncology screen
  • Enterprise license for hospital pharmacy
Read the full UpToDate Lexidrug review

Score

Each row shows points earned of points available under the published rubric.

Medscape Drug Interaction Checker

20of 100

UpToDate Lexidrug

34of 100
Score by dimension for Medscape Drug Interaction Checker and UpToDate Lexidrug
DimensionMedscape Drug Interaction CheckerUpToDate LexidrugDifference
EHR integrations (count)0 / 4.20 / 4.20
Top-3 EHR coverage (Epic / Oracle / Athena)0 / 2.40 / 2.40
Peer-reviewed papers0 / 210 / 210
RCT / meta-analysis / systematic review0 / 60 / 60
Funding & adoption signal10.9 / 15.615.6 / 15.6-4.7
Pricing transparency0 / 63 / 6-3

Scroll horizontally to see every column.

How scores are computed

Pricing

Medscape Drug Interaction Checker

TierMonthlyAnnualNotes
FreeNot statedNot statedFree to use per third-party sources (registration may be required). The Medscape page itself states no price.

UpToDate Lexidrug

TierMonthlyAnnualNotes
EnterpriseNot statedNot statedNo public price, contact form only. Personal subscriptions are also sold (mobile app and store.uptodate.com), but the current personal price is not confirmed.

Compliance and integrations

Documented from each vendor’s own pages.

SpecMedscape Drug Interaction CheckerUpToDate Lexidrug
Free tierYesNo / unverified
HIPAANo / unverifiedNo / unverified
SOC 2 Type IINo / unverifiedNo / unverified
EHR integrationsNot statedNot stated
FoundedNot statedNot stated
HQNot statedNL

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Open the full drug info comparison

Drug references (Lexidrug, Micromedex, Epocrates) and interaction checkers (Drugs.com, Medscape). Built for the clinician at the point of care.

See all drug info