AI Drug Information

Medscape Drug Interaction Checker vs UpToDate Lexidrug
Scores are legacy evidence and documentation scores, not product-performance ratings. How it is computed
The cyclosporine and lercanidipine case shows the gap. In a renal transplant study Medscape rated the pair as no interaction, while Lexicomp and Micromedex rated it severe. A pharmacist screening transplant or oncology regimens is the Lexidrug buyer, since a herb and oncology drug screening study rated Lexicomp best, and the product adds Trissel's IV compatibility, toxicology and pharmacogenomic content and an offline mobile app. Enterprise pricing goes through a contact form, and app-store listings show a personal subscription at $29.99 per month. Medscape is free per third-party comparisons, covers drugs, OTC products, herbal supplements and common foods in five severity tiers, and names the mechanism. That study still called it the best free tool, and a 2016 comparison counted 202 of 400 interactions for it, on older versions, behind Lexicomp and Micromedex. Lexidrug is the poorer value for a pharmacy student or resident, who gets a first screen at no charge from Medscape.
Drug info · Reviewed November 1, 2026
On this page
Drug interaction lookup for prescription drugs, OTC medications, herbal supplements and some foods, with severity categories.
UpToDate Lexidrug
by Wolters Kluwer
Drug reference with interaction analysis, dosing guidance and IV compatibility, from UpToDate (formerly Lexicomp).
When to pick each one
Medscape Drug Interaction Checker
- Free to use per third-party comparisons
- Mechanism shown for each interaction
- Five severity tiers, Contraindicated to Minor
UpToDate Lexidrug
- Trissel's IV compatibility and renal dosing guidance
- Lexicomp rated best in a herb and oncology screen
- Enterprise license for hospital pharmacy
Score
Each row shows points earned of points available under the published rubric.
Medscape Drug Interaction Checker
UpToDate Lexidrug
| Dimension | Medscape Drug Interaction Checker | UpToDate Lexidrug | Difference |
|---|---|---|---|
| EHR integrations (count) | 0 / 4.2 | 0 / 4.2 | 0 |
| Top-3 EHR coverage (Epic / Oracle / Athena) | 0 / 2.4 | 0 / 2.4 | 0 |
| Peer-reviewed papers | 0 / 21 | 0 / 21 | 0 |
| RCT / meta-analysis / systematic review | 0 / 6 | 0 / 6 | 0 |
| Funding & adoption signal | 10.9 / 15.6 | 15.6 / 15.6 | -4.7 |
| Pricing transparency | 0 / 6 | 3 / 6 | -3 |
Scroll horizontally to see every column.
Pricing
Medscape Drug Interaction Checker
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Free | Not stated | Not stated | Free to use per third-party sources (registration may be required). The Medscape page itself states no price. |
UpToDate Lexidrug
| Tier | Monthly | Annual | Notes |
|---|---|---|---|
| Enterprise | Not stated | Not stated | No public price, contact form only. Personal subscriptions are also sold (mobile app and store.uptodate.com), but the current personal price is not confirmed. |
Compliance and integrations
Documented from each vendor’s own pages.
| Spec | Medscape Drug Interaction Checker | UpToDate Lexidrug |
|---|---|---|
| Free tier | Yes | No / unverified |
| HIPAA | No / unverified | No / unverified |
| SOC 2 Type II | No / unverified | No / unverified |
| EHR integrations | Not stated | Not stated |
| Founded | Not stated | Not stated |
| HQ | Not stated | NL |
Scroll horizontally to see both columns.
Open the full drug info comparison
Drug references (Lexidrug, Micromedex, Epocrates) and interaction checkers (Drugs.com, Medscape). Built for the clinician at the point of care.
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